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PR-104

Known as: PR104 
A non-toxic, small-molecule, hypoxia-activated, 3,5-dinitrobenzamide nitrogen mustard pre-prodrug with potential antitumor activity. Upon intravenous… 
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Cancer is considered as one of the most serious health problems today. The discovery of nitrogen mustard as an alkylating agent… 
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2015
2015
PR-104 is a clinical stage bioreductive prodrug that is converted in vivo to its cognate alcohol, PR-104A. This dinitrobenzamide… 
Highly Cited
2015
Highly Cited
2015
We previously demonstrated vast expansion of hypoxic areas in the leukemic microenvironment and provided a rationale for using… 
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Review
2014
Review
2014
Hypoxia, a state of low oxygen, is a common feature of solid tumors and is associated with disease progression as well as… 
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2013
2013
Activation of prodrugs in tumors (e.g., by bioreduction in hypoxic zones) has the potential to generate active metabolites that… 
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Highly Cited
2011
Highly Cited
2011
Recent studies indicate that interactions between leukemia cells and the bone marrow (BM) microenvironment promote leukemia cell… 
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Highly Cited
2011
Highly Cited
2011
BackgroundThe phosphate ester PR-104 is rapidly converted in vivo to the alcohol PR-104A, a nitrogen mustard prodrug that is… 
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Review
2010
Review
2010
PR-104, currently in phase II clinical trials, is a phosphate ester pre-prodrug which is converted in vivo to its cognate alcohol… 
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Highly Cited
2009
Highly Cited
2009
PurposePR-104 is a “pre-prodrug” designed to be activated to a dinitrobenzamide nitrogen mustard cytotoxin by nitroreduction in… 
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Highly Cited
2007
Highly Cited
2007
Purpose: Hypoxia is a characteristic of solid tumors and a potentially important therapeutic target. Here, we characterize the… 
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