PR-104

Known as: PR104 
A non-toxic, small-molecule, hypoxia-activated, 3,5-dinitrobenzamide nitrogen mustard pre-prodrug with potential antitumor activity. Upon intravenous… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2007-2017
024620072017

Papers overview

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2015
2015
PR-104, a phosphate ester of the nitrogen mustard prodrug PR-104A, has shown evidence of efficacy in adult leukemia clinical… (More)
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2013
2013
Activation of prodrugs in tumors (e.g., by bioreduction in hypoxic zones) has the potential to generate active metabolites that… (More)
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2011
2011
BACKGROUND PR-104 is rapidly hydrolyzed to PR-104A in vivo, which is activated by reduction to the corresponding 5-hydroxylamine… (More)
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2011
2011
Recent studies indicate that interactions between leukemia cells and the bone marrow (BM) microenvironment promote leukemia cell… (More)
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2011
2011
PR-104 is activated by reductases under hypoxia or by aldo–keto reductase 1C3 (AKR1C3) to form cytotoxic nitrogen mustards… (More)
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2010
2010
PR-104, a bioreductive prodrug in clinical trial, is a phosphate ester which is rapidly metabolized to the corresponding alcohol… (More)
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2010
2010
PR-104 is the phosphate ester of a 3,5-dinitrobenzamide nitrogen mustard (PR-104A) that is reduced to active hydroxylamine and… (More)
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2009
2009
PR-104 is a “pre-prodrug” designed to be activated to a dinitrobenzamide nitrogen mustard cytotoxin by nitroreduction in hypoxic… (More)
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2008
2008
We have previously shown that spores of the nonpathogenic clostridial strain C. sporogenes genetically engineered to express the… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE Hypoxia is a characteristic of solid tumors and a potentially important therapeutic target. Here, we characterize the… (More)
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