PPP3CA protein, human

Known as: PPP3CA, Protein Phosphatase 3 Catalytic Subunit Alpha Isoform, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform protein, human 
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (521 aa, ~59 kDa) is encoded by the human PPP3CA gene. This protein is… (More)
National Institutes of Health

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Alzheimer's Disease Pathway KEGGApoptosisAxon GuidanceB Cell Receptor Signaling Pathway
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Calcineurin

Papers overview

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2018
2018
Loss-of-function and gain-of-function mutations in PPP3CA cause two distinct disorders.
Calcineurin is a calcium (Ca2+)/calmodulin-regulated protein phosphatase that mediates Ca2+-dependent signal transduction. Here… (More)
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2018
2018
Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression
PPP3CA encodes calmodulin-binding catalytic subunit of calcineurin, a ubiquitously expressed calcium/calmodulin-regulated protein… (More)
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2017
2017
De Novo Mutations in PPP3CA Cause Severe Neurodevelopmental Disease with Seizures.
Exome sequencing has readily enabled the discovery of the genetic mutations responsible for a wide range of diseases. This… (More)
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2017
2017
Exploring the genetics of feed efficiency and feeding behaviour traits in a pig line highly selected for performance characteristics
The consideration of feed efficiency traits is highly relevant in animal breeding due to economic and ecologic impacts of the… (More)
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2017
2017
Association of the PPP3CA c.249G>A variant with clinical outcomes of tacrolimus-based therapy in kidney transplant recipients
BACKGROUND The effects of genetic variants related to the pharmacodynamic mechanisms of immunosuppressive drugs on their… (More)
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2012
2012
Functional effect of mir-27b on myostatin expression: a relationship in piedmontese cattle with double-muscled phenotype
BackgroundIn Piedmontese cattle the double-muscled phenotype is an inherited condition associated to a point mutation in the… (More)
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2011
2011
Amyloid-β toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease.
Amyloid-β peptide (Aβ) toxicity and tau hyperphosphorylation are hallmarks of Alzheimer's disease (AD). How their molecular… (More)
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2010
2010
Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in…
Fine mapping of calcineurin (PPP3CA) gene identified single nucleotide polymorphisms (SNPs) and simple sequence repeat… (More)
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2008
2008
Protein phosphatase 3 differentially modulates vascular endothelial growth factor- and fibroblast growth factor 2-stimulated cell proliferation and signaling in ovine fetoplacental artery endothelial…
A critical process for vascular endothelial growth factor (VEGF)- and fibroblast growth factor 2 (FGF2)-regulated cellular… (More)
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1996
1996
Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively.
Calcineurin (also called protein phosphatase-2B) is a calmodulin-regulated protein phosphatase which plays an important role in… (More)
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