Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 210,000,600 papers from all fields of science
Search
Sign In
Create Free Account
PPP3CA protein, human
Known as:
PPP3CA
, Protein Phosphatase 3 Catalytic Subunit Alpha Isoform
, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform protein, human
Expand
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (521 aa, ~59 kDa) is encoded by the human PPP3CA gene. This protein is…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
30 relations
Alzheimer's Disease Pathway KEGG
Apoptosis
Axon Guidance
B Cell Receptor Signaling Pathway
Expand
Broader (1)
Calcineurin
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression
M. Rydzanicz
,
M. Wachowska
,
+23 authors
R. Płoski
European Journal of Human Genetics
2018
Corpus ID: 52823813
PPP3CA encodes calmodulin-binding catalytic subunit of calcineurin, a ubiquitously expressed calcium/calmodulin-regulated protein…
Expand
2018
2018
Loss-of-function and gain-of-function mutations in PPP3CA cause two distinct disorders
T. Mizuguchi
,
M. Nakashima
,
+19 authors
N. Matsumoto
Human Molecular Genetics
2018
Corpus ID: 4626835
Calcineurin is a calcium (Ca2+)/calmodulin-regulated protein phosphatase that mediates Ca2+-dependent signal transduction. Here…
Expand
2017
2017
De Novo Mutations in PPP3CA Cause Severe Neurodevelopmental Disease with Seizures.
C. Myers
,
N. Stong
,
+26 authors
E. Heinzen
American Journal of Human Genetics
2017
Corpus ID: 3679057
2017
2017
Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy
Jeong-Sun Seo
,
Seungbok Lee
,
+21 authors
A. McKee
Experimental &Molecular Medicine
2017
Corpus ID: 3527173
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder that is associated with repetitive head injury…
Expand
2016
2016
Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma.
Y. Imai
,
E. Ohta
,
+8 authors
T. Motoji
JCI Insight
2016
Corpus ID: 19876997
Multiple myeloma (MM) is a relapsed and refractory disease, one that highlights the need for developing new molecular therapies…
Expand
Review
2016
Review
2016
Action mechanisms of histone deacetylase inhibitors in the treatment of hematological malignancies
Y. Imai
,
Y. Maru
,
J. Tanaka
Cancer Science
2016
Corpus ID: 14942447
Histone deacetylases (HDACs) critically regulate gene expression by determining the acetylation status of histones. Studies have…
Expand
Highly Cited
2015
Highly Cited
2015
MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes.
Junnan Wu
,
C. Zheng
,
+9 authors
Zhihong Liu
Journal of Clinical Investigation
2015
Corpus ID: 40331703
Calcium/calcineurin signaling is critical for normal cellular physiology. Abnormalities in this pathway cause many diseases…
Expand
Highly Cited
2011
Highly Cited
2011
Amyloid-β toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease.
A. Lloret
,
M. Badia
,
+5 authors
J. Viña
Journal of Alzheimer's Disease
2011
Corpus ID: 30399744
Amyloid-β peptide (Aβ) toxicity and tau hyperphosphorylation are hallmarks of Alzheimer's disease (AD). How their molecular…
Expand
2010
2010
Fine Mapping of Calcineurin (PPP3CA) Gene Reveals Novel Alternative Splicing Patterns, Association of 5′UTR Trinucleotide Repeat With Addiction Vulnerability, and Differential Isoform Expression in…
M. Chiocco
,
Xuguang Zhu
,
+4 authors
Qing-Rong Liu
Substance Use & Misuse
2010
Corpus ID: 12763119
Fine mapping of calcineurin (PPP3CA) gene identified single nucleotide polymorphisms (SNPs) and simple sequence repeat…
Expand
Highly Cited
1996
Highly Cited
1996
Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively.
M. Wang
,
H. Yi
,
D. Guerini
,
C. Klee
,
O. Mcbride
Cytogenetics and Cell Genetics
1996
Corpus ID: 46784274
Calcineurin (also called protein phosphatase-2B) is a calmodulin-regulated protein phosphatase which plays an important role in…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE