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PPP3CA protein, human

Known as: PPP3CA, Protein Phosphatase 3 Catalytic Subunit Alpha Isoform, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform protein, human 
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (521 aa, ~59 kDa) is encoded by the human PPP3CA gene. This protein is… 
National Institutes of Health

Related topics

Related topics

30 relations
Alzheimer's Disease Pathway KEGGApoptosisAxon GuidanceB Cell Receptor Signaling Pathway

Broader (1)

Calcineurin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression
PPP3CA encodes calmodulin-binding catalytic subunit of calcineurin, a ubiquitously expressed calcium/calmodulin-regulated protein… 
2018
2018
Loss-of-function and gain-of-function mutations in PPP3CA cause two distinct disorders
Calcineurin is a calcium (Ca2+)/calmodulin-regulated protein phosphatase that mediates Ca2+-dependent signal transduction. Here… 
2017
2017
De Novo Mutations in PPP3CA Cause Severe Neurodevelopmental Disease with Seizures.
2017
2017
Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder that is associated with repetitive head injury… 
2016
2016
Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma.
Multiple myeloma (MM) is a relapsed and refractory disease, one that highlights the need for developing new molecular therapies… 
Review
2016
Review
2016
Action mechanisms of histone deacetylase inhibitors in the treatment of hematological malignancies
Histone deacetylases (HDACs) critically regulate gene expression by determining the acetylation status of histones. Studies have… 
Highly Cited
2015
Highly Cited
2015
MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes.
Calcium/calcineurin signaling is critical for normal cellular physiology. Abnormalities in this pathway cause many diseases… 
Highly Cited
2011
Highly Cited
2011
Amyloid-β toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease.
Amyloid-β peptide (Aβ) toxicity and tau hyperphosphorylation are hallmarks of Alzheimer's disease (AD). How their molecular… 
2010
2010
Fine Mapping of Calcineurin (PPP3CA) Gene Reveals Novel Alternative Splicing Patterns, Association of 5′UTR Trinucleotide Repeat With Addiction Vulnerability, and Differential Isoform Expression in…
Fine mapping of calcineurin (PPP3CA) gene identified single nucleotide polymorphisms (SNPs) and simple sequence repeat… 
Highly Cited
1996
Highly Cited
1996
Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively.
Calcineurin (also called protein phosphatase-2B) is a calmodulin-regulated protein phosphatase which plays an important role in… 
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