PPARGC1A gene

Known as: PPARGC1, PGC1, PPAR-GAMMA COACTIVATOR 1 
This gene plays a role in the regulation of nuclear receptor-dependent transcription.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2002-2018
05010020022018

Papers overview

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Highly Cited
2010
Highly Cited
2010
Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein… (More)
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Highly Cited
2007
Highly Cited
2007
Transcriptional complexes that contain peroxisome-proliferator-activated receptor coactivator (PGC)-1alpha control mitochondrial… (More)
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Highly Cited
2006
Highly Cited
2006
PPARgamma coactivator 1alpha (PGC-1alpha) is a potent stimulator of mitochondrial biogenesis and respiration. Since the… (More)
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Highly Cited
2006
Highly Cited
2006
Huntington's disease (HD) is an inherited neurodegenerative disease caused by a glutamine repeat expansion in huntingtin protein… (More)
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Highly Cited
2005
Highly Cited
2005
Homeostatic mechanisms in mammals respond to hormones and nutrients to maintain blood glucose levels within a narrow range… (More)
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Highly Cited
2004
Highly Cited
2004
PGC-1alpha is a coactivator of nuclear receptors and other transcription factors that regulates several metabolic processes… (More)
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Highly Cited
2003
Highly Cited
2003
DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however… (More)
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Highly Cited
2003
Highly Cited
2003
Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta cell dysfunction. In high-risk subjects… (More)
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Highly Cited
2003
Highly Cited
2003
Hepatic gluconeogenesis is absolutely required for survival during prolonged fasting or starvation, but is inappropriately… (More)
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Highly Cited
2003
Highly Cited
2003
Endurance exercise training induces mitochondrial biogenesis in skeletal muscle. The peroxisome proliferator activated receptor… (More)
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