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PPAR gamma

Known as: PPARgamma, Peroxisome Proliferator Activated Receptor gamma, Thiazolidinedione Receptor 
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH… 
National Institutes of Health

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Related topics

21 relations
Familial partial lipodystrophyIn BloodNR3C1 genePPARG gene

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PPARgamma2PPARgamma3Peroxisome Proliferator-Activated Receptor Gamma, humanmPPARgamma1

Papers overview

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Highly Cited
2010
Highly Cited
2010
Uteroplacental insufficiency increases visceral adiposity and visceral adipose PPARgamma2 expression in male rat offspring prior to the onset of obesity.
Highly Cited
2004
Highly Cited
2004
Glitazones Differentially Regulate Primary Astrocyte and Glioma Cell Survival
The glitazones or thiazolidinediones are ligands of the peroxisome proliferator-activated receptor γ (PPARγ). The glitazones are… 
Highly Cited
2004
Highly Cited
2004
Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma.
Loss-of-function mutations in the ligand-binding domain of human peroxisome proliferator-activated receptor gamma (PPARgamma) are… 
Highly Cited
2003
Highly Cited
2003
Ligand and Coactivator Identity Determines the Requirement of the Charge Clamp for Coactivation of the Peroxisome Proliferator-activated Receptor γ*
The activation function 2 (AF-2)-dependent recruitment of coactivator is essential for gene activation by nuclear receptors. We… 
Highly Cited
2003
Highly Cited
2003
PAT5A: A Partial Agonist of Peroxisome Proliferator-Activated Receptor γ Is a Potent Antidiabetic Thiazolidinedione Yet Weakly Adipogenic
PAT5A [5-[4-[N-(2-pyridyl)-(2S)-pyrrolidine-2-methoxyl]phenylmethylene[thiazolidine-2,4-dione, malic acid salt]], a chemically… 
Review
2002
Review
2002
Controversy: PPARgamma as a target for treatment of colorectal cancer.
Colorectal cancer (CRC) represents a significant cause of morbidity and mortality worldwide. Recently, ligands for the nuclear… 
Highly Cited
2001
Highly Cited
2001
Tetradecylthioacetic acid inhibits growth of rat glioma cells ex vivo and in vivo via PPAR-dependent and PPAR-independent pathways.
The peroxisome proliferator-activated receptors (PPARs) are transcription factors involved in fatty acid metabolism and energy… 
Highly Cited
2001
Highly Cited
2001
Troglitazone, a Ligand for Peroxisome Proliferator‐activated Receptor γ Inhibits Chemically‐induced Aberrant Crypt Foci in Rats
The biological roles of peroxisome proliferator‐activated receptors (PPARs) in various diseases, including inflammation and… 
Highly Cited
1998
Highly Cited
1998
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent.
3-¿4-[2-(Benzoxazol-2-ylmethylamino)ethoxy]phenyl¿-(2S)-((2- benzoylph enyl)amino)propionic acid (1) and (2S)-((2-benzoylphenyl… 
Highly Cited
1997
Highly Cited
1997
Increased feeding in fatty Zucker rats by the thiazolidinedione BRL 49653 (rosiglitazone) and the possible involvement of leptin and hypothalamic neuropeptide Y
1 The thiazolidinedione BRL 49653 (rosiglitazone) induces hyperphagia and weight gain in obese, insulin‐resistant fatty Zucker… 
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