POT1 gene

Known as: Protection of Telomeres Protein 1 Gene, PROTECTION OF TELOMERES 1, hPot1 
This gene plays a role in the regulation of telomere length.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in adults. We have analyzed exome sequencing data from 127… (More)
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Highly Cited
2007
Highly Cited
2007
Telomeres were originally defined as chromosome caps that prevent the natural ends of linear chromosomes from undergoing… (More)
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Highly Cited
2007
Highly Cited
2007
When telomeres are rendered dysfunctional through replicative attrition of the telomeric DNA or by inhibition of shelterin, cells… (More)
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Highly Cited
2006
Highly Cited
2006
The terminal t-loop structure adopted by mammalian telomeres is thought to prevent telomeres from being recognized as double… (More)
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Highly Cited
2006
Highly Cited
2006
Human telomeres are protected by shelterin, a complex that includes the POT1 single-stranded DNA binding protein. We found that… (More)
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Review
2005
Review
2005
Added by telomerase, arrays of TTAGGG repeats specify the ends of human chromosomes. A complex formed by six telomere-specific… (More)
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Highly Cited
2005
Highly Cited
2005
The hallmarks of telomere dysfunction in mammals are reduced telomeric 3' overhangs, telomere fusions, and cell cycle arrest due… (More)
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Highly Cited
2004
Highly Cited
2004
Human telomere length is controlled by a negative feedback loop based on the binding of TRF1 to double-stranded telomeric DNA… (More)
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Highly Cited
2004
Highly Cited
2004
Telomere maintenance has been implicated in cancer and ageing, and requires cooperation between a multitude of telomeric factors… (More)
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Highly Cited
2003
Highly Cited
2003
Human telomere maintenance is essential for the protection of chromosome ends, and changes in telomere length have been… (More)
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