POLYCYSTIC KIDNEY DISEASE 3, AUTOSOMAL DOMINANT
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Mutations to PKD1 and PKD2 are associated with autosomal dominant polycystic kidney disease (ADPKD). The absence of apparent PKD1… Expand The protein kinase D (PKD) family of serine/threonine kinases, which can be activated by gastrointestinal hormones, consists of… Expand BackgroundThe PKD family of serine/threonine kinases comprises a single member in Drosophila (dPKD), two isoforms in C. elegans… Expand Protein kinase D1 (PKD1) is a mediator of oxidative stress signaling where it regulates cellular detoxification and survival… Expand ABSTRACT We have taken a knockout approach to interrogate the function of protein kinase D (PKD) serine/threonine kinases in… Expand Protein kinase D (PKD) controls protein traffic from the trans-Golgi network (TGN) to the plasma membrane of epithelial cells in… Expand Protein kinase C (PKC) and protein kinase D (PKD) coordinate and regulate many fundamental cellular processes. In this study, we… Expand The protein kinase D (PKD) family consists of three serine/threonine kinases: PKCμ/PKD, PKD2, and PKCν/PKD3. Whereas PKD has been… Expand Abstract. Mutations in three different genes, PKD1, PKD2 and PKD3, can cause a very similar clinical picture of the autosomal… Expand Autosomal dominant polycystic kidney disease (ADPKD) is a common Mendelian disorder. Linkage studies have estimated that 80 to 85… Expand