Skip to search formSkip to main contentSkip to account menu

POLQ gene

Known as: polymerase (DNA) theta, POLH, POLQ 
National Institutes of Health

Related topics

Related topics

2 relations
DNA polymerase thetaPOLH gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
A PolH transcript with a short 3'UTR enhances PolH expression and mediates cisplatin resistance.
Platinum-based anticancer drugs are widely used as a frontline therapy for cancers such as non-small-cell lung carcinoma (NSCLC… 
2014
2014
Translesion polymerase η is upregulated by cancer therapeutics and confers anticancer drug resistance.
DNA repair processes are a key determinant of the sensitivity of cancer cells to DNA-damaging chemotherapeutics, which may induce… 
2013
2013
Characterization of a Trichoplusia ni hexamerin-derived promoter in the AcMNPV baculovirus vector.
Highly Cited
2012
Highly Cited
2012
DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation.
Highly Cited
2011
Highly Cited
2011
Pirh2 E3 Ubiquitin Ligase Monoubiquitinates DNA Polymerase Eta To Suppress Translesion DNA Synthesis
ABSTRACT Polymerase eta (PolH) is necessary for translesion DNA synthesis, and PolH deficiency predisposes xeroderma pigmentosum… 
Highly Cited
2009
Highly Cited
2009
Pirh2 E3 Ubiquitin Ligase Targets DNA Polymerase Eta for 20S Proteasomal Degradation
ABSTRACT DNA polymerase eta (PolH), a Y family translesion polymerase, is required for repairing UV-induced DNA damage, and loss… 
2009
2009
Variants of the xeroderma pigmentosum variant gene (POLH) are associated with melanoma risk.
Highly Cited
2006
Highly Cited
2006
DNA Polymerase η, the Product of the Xeroderma Pigmentosum Variant Gene and a Target of p53, Modulates the DNA Damage Checkpoint and p53 Activation
ABSTRACT DNA polymerase η (PolH) is the product of the xeroderma pigmentosum variant (XPV) gene and a well-characterized Y-family… 
2005
2005
Overproduction of DNA polymerase eta does not raise the spontaneous mutation rate in diploid human fibroblasts.
Review
2003
Review
2003
POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells.
The genomes of eukaryotic cells predict the existence of multiple DNA polymerases, which are proposed to serve specialized roles… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)