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POLK gene

Known as: POLQ, DINP, polymerase (DNA) kappa 
This gene is involved in translesion DNA synthesis.
National Institutes of Health

Related topics

Related topics

5 relations
DNA Polymerase KappaDNA RepairDNA ReplicationNucleotide Excision Repair

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Abstract I14: Polymerase theta synthetic lethal interaction in homologous recombination-deficient pancreatic ductal adenocarcinoma
Recent genomic characterization of PDA reveals that between 20-25 % of PDA harbor recurrent mutations in genes, including BRCA1/2… 
2011
2011
Comparison of two POLQ mutants reveals that a polymerase‐inactive POLQ retains significant function in tolerance to etoposide and γ‐irradiation in mouse B cells
DNA polymerase θ (POLQ) is a family A polymerase that contains an intrinsic helicase domain. POLQ has been implicated in… 
2008
2008
DNA polymerase theta (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproduct.
DNA polymerase theta (pol theta) is a nuclear A-family DNA polymerase encoded by the POLQ gene in vertebrate cells. The… 
2007
2007
DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes.
Somatic hypermutation of the Ig genes requires the activity of multiple DNA polymerases to ultimately introduce mutations at both… 
Highly Cited
2002
Highly Cited
2002
Human DNA Polymerase κ Bypasses and Extends beyond Thymine Glycols during Translesion Synthesis in Vitro, Preferentially Incorporating Correct Nucleotides*
Human polymerase κ (polκ), the product of the human POLK (DINB1) gene, is a member of the Y superfamily of DNA polymerases that… 
2001
2001
Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 gene.
The Escherichia coli dinB gene encodes DNA polymerase (pol) IV, a protein involved in increasing spontaneous mutations in vivo… 
Review
2000
Review
2000
Human DNA polymerase kappa: a novel DNA polymerase of unknown biological function encoded by the DINB1 gene.
Highly Cited
1999
Highly Cited
1999
Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily.
To understand the mechanisms underlying mutagenesis in eukaryotes better, we have cloned mouse and human homologs of the… 
1997
1997
Biodegradation of DEHP, DBP, and DINP: Poorly Water Soluble and Widely Used Phthalate Plasticizers
Highly Cited
1995
Highly Cited
1995
dinP, a new gene in Escherichia coli, whose product shows similarities to UmuC and its homologues.
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