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POLH protein, human

Known as: XP-V protein, human, DNA Polymerase Eta, polymerase (DNA directed), eta protein, human 
DNA polymerase eta (713 aa, ~78 kDa) is encoded by the human POLH gene. This protein plays a role in repair of UV-induced pyrimidine dimers in DNA.
National Institutes of Health

Related topics

Related topics

10 relations
DNA RepairDNA Repair GeneDNA-Directed DNA PolymeraseEnzyme Gene

Broader (1)

Rad30 protein

Papers overview

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2008
2008
A role for PCNA2 in translesion synthesis by Arabidopsis thaliana DNA polymerase η
Eukaryotic DNA polymerase η (Polη) confers ultraviolet (UV) resistance by catalyzing translesion synthesis (TLS) past UV… 
2006
2006
The Saccharomyces cerevisiae rev6-1 Mutation, Which Inhibits Both the Lesion Bypass and the Recombination Mode of DNA Damage Tolerance, Is an Allele of POL30, Encoding Proliferating Cell Nuclear…
The rev6-1 allele was isolated in a screen for mutants deficient for UV-induced reversion of the frameshift mutation his4-38… 
2005
2005
Error-prone Translesion Synthesis by Human DNA Polymerase η on DNA-containing Deoxyadenosine Adducts of 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene*
When human DNA polymerase η (pol η) encounters N6-deoxyadenosine adducts formed by trans epoxide ring opening of the 7,8… 
2003
2003
Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta.
DNA polymerase eta (Pol eta) is a member of a new class of DNA polymerases that is able to copy DNA containing damaged… 
2003
2003
Utilization efficiency of the oxidized purine nucleotide analogs by DNA polymerase eta.
To elucidate the behavior of DNA polymerase eta against the oxidized purine nucleotides, we determined the utilization efficiency… 
2003
2003
Translesion synthesis past acrolein-derived DNA adduct, gamma -hydroxypropanodeoxyguanosine, by yeast and human DNA polymerase eta.
gamma-Hydroxy-1,N(2)-propano-2'deoxyguanosine (gamma-HOPdG) is a major deoxyguanosine adduct derived from acrolein, a known… 
Review
2002
Review
2002
Molecular mechanisms of UV-induced mutations as revealed by the study of DNA polymerase eta in human cells.
2001
2001
Proofreading of DNA polymerase eta-dependent replication errors.
Human DNA polymerase eta, the product of the skin cancer susceptibility gene XPV, bypasses UV photoproducts in template DNA that… 
Highly Cited
2001
Highly Cited
2001
Acidic Residues Critical for the Activity and Biological Function of Yeast DNA Polymerase η
ABSTRACT Rad30 is a member of the newly discovered UmuC/DinB/Rad30 family of DNA polymerases. The N-terminal regions of these… 
2001
2001
Translesion DNA Synthesis by Yeast DNA Polymerase η on Templates Containing N 2-Guanine Adducts of 1,3-Butadiene Metabolites*
Yeast DNA polymerase η can replicate throughcis-syn cyclobutane pyrimidine dimers and 8-oxoguanine lesions with the same… 
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