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PNU 159548

Known as: PNU-159548 
 
National Institutes of Health

Papers overview

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2005
2005
4-Demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548): a promising new candidate for chemotherapeutic treatment of osteosarcoma patients.
The effectiveness of the alkycycline 4-demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548… Expand
2003
2003
Predicting the maximum-tolerated dose of PNU-159548 (4-demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin) in humans using CFU-GM clonogenic assays and prospective validation.
A haematotoxicity model was proposed by Parchment in 1998 to predict the maximum-tolerated dose (MTD) in humans of… Expand
2002
2002
Phase I and pharmacokinetic studies of PNU-159548, a novel alkycycline, administered intravenously to patients with advanced solid tumours.
PNU-159548 (4-demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin) is the lead compound of a novel class of… Expand
2001
2001
Pharmacological and toxicological aspects of 4-demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548): a novel antineoplastic agent.
4-demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548) belongs to a novel class of antitumor compounds… Expand
2001
2001
4-Demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548), a novel anticancer agent active against tumor cell lines with different resistance mechanisms.
The activity of 4-demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548), a new alkycycline with high… Expand
2001
2001
PNU-159548, a novel cytotoxic antitumor agent with a low cardiotoxic potential
Purpose: PNU-159548 (4-demethoxy-3'-deamino-3'aziridinyl-4'-methylsulphonyl-daunorubicin), a derivative of the anticancer… Expand
2001
2001
Pharmacological and Toxicological Aspects of 4-Demethoxy-3 *-deamino-3 *-aziridinyl-4 *-methylsulphonyl-daunorubicin ( PNU-159548 ) : A Novel Antineoplastic Agent 1
4-demethoxy-3*-deamino-3*-aziridinyl-4*-methylsulphonyl-daunorubicin (PNU-159548) belongs to a novel class of antitumor compounds… Expand
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1999
1999
Determination of 4-demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyldaunorubicin+ ++ and its 13-hydroxy metabolite by direct injection of human plasma into a column-switching liquid…
A selective, sensitive and fully automated column-switching LC system using direct injection of human plasma followed by mass… Expand
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