PNT2258

Known as: DNA Interference Oligonucleotide PNT2258 
A liposomal formulation of the 24-mer oligonucleotide PNT100, with potential antineoplastic activity. PNT2258 targets and complements to… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2013-2016
01220132016

Papers overview

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2017
2017
INTRODUCTION Previous research suggested that a novel compound PNT2258 inhibits B-cell lymphoma 2 (BCL-2) transcription by DNA… (More)
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2016
2016
Current therapy for BCL-2-associated tumors such as Non-Hodgkin Lymphomas (NHL) is inadequate. The DNAi PNT2258, a 24 base single… (More)
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Review
2016
Review
2016
BCL-2 is the founding member of the BCL-2 family of apoptosis regulatory proteins that either induce (pro-apoptotic) or inhibit… (More)
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2014
2014
PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to a region upstream of the BCL-2… (More)
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2013
2013
Maximum tolerated dose, safety, pharmacokinetics, and pharmacodynamics were assessed in this phase 1 study of PNT2258, a BCL-2… (More)
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