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PNT2258

Known as: DNA Interference Oligonucleotide PNT2258 
A liposomal formulation of the 24-mer oligonucleotide PNT100, with potential antineoplastic activity. PNT2258 targets and complements to… Expand
National Institutes of Health

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2017
2017
INTRODUCTION Previous research suggested that a novel compound PNT2258 inhibits B-cell lymphoma 2 (BCL-2) transcription by DNA… Expand
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2017
2017
TPS3110 Background: With the knowledge that Bcl-2 facilitates drug resistance and cell survival, a DNA interference (DNAi… Expand
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2016
2016
Current therapy for BCL-2-associated tumors such as Non-Hodgkin Lymphomas (NHL) is inadequate. The DNAi PNT2258, a 24 base single… Expand
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2016
2016
TPS7577Background: PNT2258, a liposomal encapsulated DNA interference (DNAi) oligonucleotide nanoparticle targeting the BCL2… Expand
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2014
2014
PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to a region upstream of the BCL-2… Expand
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2014
2014
2586 Background: PNT2258 contains PNT100, a DNA interference (DNAi) oligonucleotide encapsulated in a lipid nanoparticle. PNT2258… Expand
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2013
2013
PurposeMaximum tolerated dose, safety, pharmacokinetics, and pharmacodynamics were assessed in this phase 1 study of PNT2258, a… Expand
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2013
2013
Background Aberrant BCL2 control mechanisms are a defining characteristic of a variety of cancers including follicular lymphoma… Expand
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2013
2013
Background: The dysregulation of apoptosis is a defining characteristic of malignant cells where excessive concentration of BCL2… Expand
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2012
2012
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Bcl-2 and bcl-XL are anti-apoptotic proteins that… Expand
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