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PNT2258
Known as:
DNA Interference Oligonucleotide PNT2258
A liposomal formulation of the 24-mer oligonucleotide PNT100, with potential antineoplastic activity. PNT2258 targets and complements to…
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National Institutes of Health
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PNT100
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Unintended target effect of anti-BCL-2 DNAi
A. Ebrahim
,
M. Kandouz
,
Nada Emara
,
Amara B Sugalski
,
L. Lipovich
,
A. Al-Katib
Cancer management and research
2017
Corpus ID: 29814906
Introduction Previous research suggested that a novel compound PNT2258 inhibits B-cell lymphoma 2 (BCL-2) transcription by DNA…
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2016
2016
PNT2258, a novel deoxyribonucleic acid inhibitor, induces cell cycle arrest and apoptosis via a distinct mechanism of action: a new class of drug for non-Hodgkin's lymphoma
A. Ebrahim
,
M. Kandouz
,
+4 authors
A. Al-Katib
Oncotarget
2016
Corpus ID: 9917797
Current therapy for BCL-2-associated tumors such as Non-Hodgkin Lymphomas (NHL) is inadequate. The DNAi PNT2258, a 24 base single…
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Review
2016
Review
2016
Hematologic malignancies: newer strategies to counter the BCL-2 protein
A. Ebrahim
,
H. Sabbagh
,
Allison Liddane
,
A. Raufi
,
M. Kandouz
,
A. Al-Katib
Journal of Cancer Research and Clinical Oncology
2016
Corpus ID: 24086894
IntroductionBCL-2 is the founding member of the BCL-2 family of apoptosis regulatory proteins that either induce (pro-apoptotic…
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2016
2016
A phase 2 study of PNT2258 in patients with relapsed or refractory (r/r) diffuse large b-cell lymphoma (DLBCL): An initial report from the Wolverine study.
J. Westin
,
M. Maris
,
+7 authors
B. Klencke
2016
Corpus ID: 81946253
TPS7577Background: PNT2258, a liposomal encapsulated DNA interference (DNAi) oligonucleotide nanoparticle targeting the BCL2…
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2014
2014
Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide
W. Rodrigueza
,
Michael J. Woolliscroft
,
+22 authors
A. Al-Katib
Cancer Chemotherapy and Pharmacology
2014
Corpus ID: 1283243
PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to a region upstream of the BCL-2…
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2014
2014
Pharmacokinetics of the BCL2-targeted DNA interference (DNAi) nanoparticle PNT2258 in patients with recurrent or refractory non-Hodgkin lymphoma.
W. Harb
,
N. Lakhani
,
+8 authors
A. Al-Katib
2014
Corpus ID: 81874719
2586 Background: PNT2258 contains PNT100, a DNA interference (DNAi) oligonucleotide encapsulated in a lipid nanoparticle. PNT2258…
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Highly Cited
2013
Highly Cited
2013
A phase 1 study of the BCL2-targeted deoxyribonucleic acid inhibitor (DNAi) PNT2258 in patients with advanced solid tumors
A. Tolcher
,
W. Rodrigueza
,
+9 authors
R. Messmann
Cancer Chemotherapy and Pharmacology
2013
Corpus ID: 17324164
PurposeMaximum tolerated dose, safety, pharmacokinetics, and pharmacodynamics were assessed in this phase 1 study of PNT2258, a…
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2013
2013
The BCL2 Targeted Deoxyribonucleic Acid Inhibitor (DNAi) PNT2258 Is Active in Patients with Relapsed or Refractory Non-Hodgkin’s Lymphoma
W. Harb
,
N. Lakhani
,
+8 authors
A. Al-Katib
2013
Corpus ID: 70809464
Background Aberrant BCL2 control mechanisms are a defining characteristic of a variety of cancers including follicular lymphoma…
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2012
2012
Abstract 2764: Effect of PNT2258 combinations with docetaxel, dacarbazine, or vemurafenib on the A375 melanoma xenograft
W. Rodrigueza
,
C. Whitehead
,
+5 authors
C. Bisgaier
2012
Corpus ID: 72408979
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Bcl-2 and bcl-XL are anti-apoptotic proteins that…
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2012
2012
Design of a phase I clinical trial with PNT2258, a novel DNA interference oligonucleotide (DNAi), in patients with advanced solid tumors.
D. Rasco
,
A. Tolcher
,
+8 authors
W. Rodrigueza
2012
Corpus ID: 91056539
TPS3110 Background: With the knowledge that Bcl-2 facilitates drug resistance and cell survival, a DNA interference (DNAi…
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