PLK2 gene

Known as: Polo-Like Kinase 2 (Drosophila) Gene, polo like kinase 2, POLO-LIKE KINASE 2 
This gene is involved in normal cell division.
National Institutes of Health

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5 relations
PLK2 protein, humanPhosphorylationSerine/Threonine PhosphorylationSignal Transduction

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PLK2 wt Allele

Papers overview

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2011
2011
Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop.
Aberrant activation of kinases has emerged to be a key event along with tumor progression, maintenance of tumor phenotype and… (More)
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2011
2011
Characterization of kinases involved in the phosphorylation of aggregated α-synuclein.
α-Synuclein (α-syn) is the major component of pathological inclusions characteristic of several neurodegenerative disorders, such… (More)
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2011
2011
Polo-like kinase Plk2 is an epigenetic determinant of chemosensitivity and clinical outcomes in ovarian cancer.
Resistance to platinum- and taxane-based chemotherapy remains a major clinical impediment to effective management of epithelial… (More)
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2010
2010
PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle.
Control of centrosome duplication is tightly linked with the progression of the cell cycle. Recent studies suggest that the… (More)
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2010
2010
Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model
α-Synuclein aggregates in Lewy bodies and plays a central role in the pathogenesis of a group of neurodegenerative disorders… (More)
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Highly Cited
2009
Highly Cited
2009
Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System*S⃞
Several neurological diseases, including Parkinson disease and dementia with Lewy bodies, are characterized by the accumulation… (More)
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Highly Cited
2009
Highly Cited
2009
Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines
Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by abnormalities in reciprocal social interactions… (More)
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2009
2009
The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions.
Tuberous sclerosis complex 1 (TSC1) inhibits mammalian target of rapamycin (mTOR), a central promotor of cell growth and… (More)
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2008
2008
Plk2 regulated centriole duplication is dependent on its localization to the centrioles and a functional polo-box domain.
In mammalian cells, the centrosome consists of a pair of centrioles and amorphous pericentriolar material. The centrosome… (More)
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2007
2007
Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells.
We previously reported that the Polo-like Kinase 2 gene (Plk2/Snk) is a direct target for transcriptional regulation by p53 and… (More)
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