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PLA2G6 gene

Known as: iPLA2beta, NBIA2, PARK14 
This gene plays a role in apoptosis and membrane remodeling.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
The 2 major types of neurodegeneration with brain iron accumulation (NBIA) are the pantothenate kinase type 2 (PANK2)-associated… Expand
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Highly Cited
2011
Highly Cited
2011
Objective: Mutations in the PLA2G6 gene at the PARK14 locus have been reported in complicated parkinsonism. To assess the… Expand
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Highly Cited
2010
Highly Cited
2010
Background: PLA2G6 is the causative gene for infantile neuroaxonal dystrophy, neurodegeneration associated with brain iron… Expand
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Highly Cited
2009
Highly Cited
2009
Although many recessive loci causing parkinsonism dystonia have been identified, these do not explain all cases of the disorder. 
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Highly Cited
2009
Highly Cited
2009
Quantitative and qualitative alterations of mitochondrial cardiolipin have been implicated in the pathogenesis of Barth syndrome… Expand
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Highly Cited
2007
Highly Cited
2007
PLA2 (phospholipase A2) enzymes play critical roles in membrane phospholipid homoeostasis and in generation of lysophospholipid… Expand
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Highly Cited
2006
Highly Cited
2006
Infantile neuroaxonal dystrophy (INAD) is an autosomal recessive progressive neurodegenerative disease that presents within the… Expand
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Highly Cited
2006
Highly Cited
2006
Mitochondria-mediated production of reactive oxygen species (ROS) plays a key role in apoptosis. Mitochondrial phospholipid… Expand
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Highly Cited
2004
Highly Cited
2004
Acute inflammation can be considered in terms of a series of checkpoints where each phase of cellular influx, persistence, and… Expand
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Review
2001
Review
2001
  • Z. Ma, J. Turk
  • Progress in nucleic acid research and molecular…
  • 2001
  • Corpus ID: 25814478
The group VIA PLA2 is a member of the PLA2 superfamily. This enzyme, which is cytosolic and Ca2+-independent, has been designated… Expand
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