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PLA2G2A protein, human

Known as: phospholipase A2, group IIA (platelets, synovial fluid) protein, human, Membrane Associated Phospholipase A2, PLAS1 
Phospholipase A2, membrane associated (144 aa, ~16 kDa) is encoded by the human PLA2G2A gene. This protein plays a role in the metabolism of… 
National Institutes of Health

Related topics

Related topics

23 relations
Arachidonic Acid Metabolism PathwayEnzyme GeneEsterase GeneGlycerolipid Metabolism Pathway

Broader (1)

Group II Phospholipases A2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Evidence for the Regulatory Role of the N-terminal Helix of Secretory Phospholipase A2 from Studies on Native and Chimeric Proteins*
The phospholipase A2 (PLA2) enzymes are activated by binding to phospholipid membranes. Although the N-terminal α-helix of group… 
2005
2005
Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A2 homologues are reduced, but not abolished, by a pH-induced dissociation.
2003
2003
A structure based model for liposome disruption and the role of catalytic activity in myotoxic phospholipase A2s.
Review
2002
Review
2002
Group IV cytosolic phospholipase A2 (PLA2) function: insights from the knockout mouse.
The phospholipases A2 (PLA2s) comprise a growing enzyme superfamily1. PLA2s hydrolyze ester linked acyl groups at thesn-2position… 
Highly Cited
1996
Highly Cited
1996
Asp-49 is not an absolute prerequisite for the enzymic activity of low-M(r) phospholipases A2: purification, characterization and computer modelling of an enzymically active Ser-49 phospholipase A2…
Several studies have shown that Asp-49 is the residue that controls calcium binding in, and so plays a critical role in the… 
Highly Cited
1994
Highly Cited
1994
Inhibition of human secretory class II phospholipase A2 by heparin.
By means of kinetic analyses using Triton X-100/deoxycholic acid/dilauroylglycerophosphoethanolamine (4:2:1, molar ratio) mixed… 
Highly Cited
1994
Highly Cited
1994
Characterization of phospholipase A2 from human nasal lavage.
A secreted form of phospholipase A2 (PLA2) has been implicated in inflammatory disorders such as rheumatoid arthritis and sepsis… 
1993
1993
Purification, sequencing and characterization of single amino acid-substituted phospholipase A2 isozymes from Trimeresurus gramineus (green habu snake) venom.
Highly Cited
1992
Highly Cited
1992
Characterization of a high affinity binding site for pancreatic-type phospholipase A2 in the rat. Its cellular and tissue distribution.
Review
1992
Review
1992
Regulation of extracellular phospholipase A2 activity: implications for inflammatory diseases.
Phospholipases A2 (PLA2s; E.C.3.1.1.4) are a family of esterases that are involved in myriads of physiological and pathological… 
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