PKN1 gene

Known as: PROTEIN KINASE N1, SERINE/THREONINE PROTEIN KINASE N, PKN-ALPHA 
This gene is involved in the phosphorylation of cytoskeletal intermediate filaments, cell migration and histone modification.
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
The Akt/PKB isoforms have different roles in animals, with Akt2 primarily regulating metabolic signaling and Akt1 regulating… (More)
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Highly Cited
2005
Highly Cited
2005
Previously, we showed PAK-PIX-GIT targets and regulates focal adhesions; here, we uncover a different function for the complex at… (More)
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Highly Cited
2003
Highly Cited
2003
Efficient chemotaxis requires directional sensing and cell polarization. We describe a signaling mechanism involving G beta gamma… (More)
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Highly Cited
2003
Highly Cited
2003
The p21-activated protein kinases (Paks) regulate cellular proliferation, differentiation, transformation, and survival through… (More)
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Highly Cited
2003
Highly Cited
2003
Members of the Snf1/AMP-activated protein kinase family are activated under conditions of nutrient stress by a distinct upstream… (More)
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Highly Cited
2002
Highly Cited
2002
Pak1, a serine/threonine kinase that regulates the actin cytoskeleton, is an effector of the Rho family GTPases Cdc42 and Rac1… (More)
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Highly Cited
2000
Highly Cited
2000
The p21-activated kinases (PAKs), stimulated by binding with GTP-liganded forms of Cdc42 or Rac, modulate cytoskeletal actin… (More)
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Review
2000
Review
2000
the discovery that PDK-1 is the Akt/PKB upstream ki-Harvard Medical School nase came the observation that PDK-1 also phosphory… (More)
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Highly Cited
1998
Highly Cited
1998
PAKs are serine/threonine protein kinases that are activated by binding to Rac or Cdc42hs. Different forms of activated PAK1 have… (More)
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Highly Cited
1996
Highly Cited
1996
The p21-activated kinases (PAKs) link G protein-coupled receptors and growth factor receptors (S. Dharmawardhane, R. H. Daniels… (More)
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