Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

PKI 166

Known as: PKI-166, PKI166 
A pyrrolo-pyrimidine epidermal growth factor receptor (EGFR) protein kinase inhibitor with anti-tumor activity.PKI-166 reversibly inhibits HER1 and… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Background—We previously reported that administration of elastase inhibitors reverses fatal pulmonary arterial hypertension (PAH… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2005
Highly Cited
2005
How do myelinated axons signal to the nuclei of cells that enwrap them? The cell bodies of oligodendrocytes and Schwann cells are… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2004
Highly Cited
2004
The epidermal growth factor receptor (EGFR) has been proposed as a key modulator of cadherin-containing intercellular junctions… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Highly Cited
2004
Highly Cited
2004
Given the role of the EGFR/HER2 family of tyrosine kinases in breast cancer, we dissected the molecular basis of EGFR/HER2 kinase… Expand
Highly Cited
2002
Highly Cited
2002
The ErbB1 and ErbB2 receptor tyrosine kinases (RTKs) play important roles in the development of numerous types of human cancer… Expand
Review
2001
Review
2001
Protein kinases play a crucial role in signal transduction as well as in cellular proliferation, differentiation, and various… Expand
Highly Cited
2000
Highly Cited
2000
We determined whether down-regulation of the epidermal growth factor-receptor (EGF-R) signaling pathway by oral administration of… Expand
  • figure 1
  • table 1
  • table 2
  • table 3
  • figure 2
Highly Cited
1990
Highly Cited
1990
Synthetic peptides corresponding to the autoinhibitory domains of calcium/calmodulin-dependent protein kinase II (CaMK-(281-309… Expand
Highly Cited
1989
Highly Cited
1989
Perturbing the changes in protein phosphorylation accompanying the first cleavage can inhibit the appearance of a set of proteins… Expand
Highly Cited
1988
Highly Cited
1988
Maturation-promoting factor causes germinal vesicle breakdown when injected into Xenopus oocytes and can induce metaphase in a… Expand
  • table 1
  • figure 2
  • figure 1