FAQ

PKI 166

Known as: PKI-166, PKI166 
A pyrrolo-pyrimidine epidermal growth factor receptor (EGFR) protein kinase inhibitor with anti-tumor activity.PKI-166 reversibly inhibits HER1 and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2017
05101519862017

Related topics

Related topics

3 relations

Broader (2)

PyrimidinesPyrroles
Receptor Tyrosine Kinase Inhibition

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
PKI 166
Pyrimidines
Pyrroles
Receptor Tyrosine Kinase Inhibition

Papers overview

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Highly Cited
2005
Highly Cited
2005
Microanatomy of axon/glial signaling during Wallerian degeneration.
How do myelinated axons signal to the nuclei of cells that enwrap them? The cell bodies of oligodendrocytes and Schwann cells are… (More)
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Highly Cited
2005
Highly Cited
2005
Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension.
BACKGROUND We previously reported that administration of elastase inhibitors reverses fatal pulmonary arterial hypertension (PAH… (More)
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Highly Cited
2005
Highly Cited
2005
CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation.
Experimental evidence suggests that CXCR4, a Gi protein-coupled receptor for the ligand CXCL12/stromal cell-derived factor-1alpha… (More)
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Highly Cited
2004
Highly Cited
2004
HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability.
Given the role of the EGFR/HER2 family of tyrosine kinases in breast cancer, we dissected the molecular basis of EGFR/HER2 kinase… (More)
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Highly Cited
2004
Highly Cited
2004
Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells.
The epidermal growth factor receptor (EGFR) has been proposed as a key modulator of cadherin-containing intercellular junctions… (More)
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2004
2004
Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer…
Once prostate cancer metastasizes to bone, conventional chemotherapy is largely ineffective. We hypothesized that inhibition of… (More)
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Highly Cited
2002
Highly Cited
2002
The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides.
The ErbB1 and ErbB2 receptor tyrosine kinases (RTKs) play important roles in the development of numerous types of human cancer… (More)
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2002
2002
Growth inhibitory effects of the dual ErbB1/ErbB2 tyrosine kinase inhibitor PKI-166 on human prostate cancer xenografts.
Experiments with human prostate cancer cell lines have shown that forced overexpression of the ErbB2-receptor tyrosine kinase… (More)
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Highly Cited
2002
Highly Cited
2002
Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer.
We determined whether concurrent blockage of vascular endothelial growth factor (VEGF) receptor and epidermal growth factor (EGF… (More)
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2001
2001
Mammary glands reconstituted with Neu/ErbB2 transformed HC11 cells provide a novel orthotopic tumor model for testing anti-cancer agents
The ErbB2 receptor tyrosine kinase (RTK) has been intensely pursued as a cancer therapy target due to its association with breast… (More)
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