PKI 166

Known as: PKI-166, PKI166 
A pyrrolo-pyrimidine epidermal growth factor receptor (EGFR) protein kinase inhibitor with anti-tumor activity.PKI-166 reversibly inhibits HER1 and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2017
05101519862017

Papers overview

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Highly Cited
2005
Highly Cited
2005
How do myelinated axons signal to the nuclei of cells that enwrap them? The cell bodies of oligodendrocytes and Schwann cells are… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND We previously reported that administration of elastase inhibitors reverses fatal pulmonary arterial hypertension (PAH… (More)
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Highly Cited
2005
Highly Cited
2005
Experimental evidence suggests that CXCR4, a Gi protein-coupled receptor for the ligand CXCL12/stromal cell-derived factor-1alpha… (More)
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Highly Cited
2004
Highly Cited
2004
Given the role of the EGFR/HER2 family of tyrosine kinases in breast cancer, we dissected the molecular basis of EGFR/HER2 kinase… (More)
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Highly Cited
2004
Highly Cited
2004
The epidermal growth factor receptor (EGFR) has been proposed as a key modulator of cadherin-containing intercellular junctions… (More)
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2004
2004
Once prostate cancer metastasizes to bone, conventional chemotherapy is largely ineffective. We hypothesized that inhibition of… (More)
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Highly Cited
2002
Highly Cited
2002
The ErbB1 and ErbB2 receptor tyrosine kinases (RTKs) play important roles in the development of numerous types of human cancer… (More)
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2002
2002
Experiments with human prostate cancer cell lines have shown that forced overexpression of the ErbB2-receptor tyrosine kinase… (More)
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Highly Cited
2002
Highly Cited
2002
We determined whether concurrent blockage of vascular endothelial growth factor (VEGF) receptor and epidermal growth factor (EGF… (More)
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2001
2001
The ErbB2 receptor tyrosine kinase (RTK) has been intensely pursued as a cancer therapy target due to its association with breast… (More)
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