Skip to search formSkip to main contentSkip to account menu

PKI 166

Known as: PKI-166, PKI166 
A pyrrolo-pyrimidine epidermal growth factor receptor (EGFR) protein kinase inhibitor with anti-tumor activity.PKI-166 reversibly inhibits HER1 and… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

PyrimidinesPyrroles
Receptor Tyrosine Kinase Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Epidermal Growth Factor Receptor Blockade Mediates Smooth Muscle Cell Apoptosis and Improves Survival in Rats With Pulmonary Hypertension
Background—We previously reported that administration of elastase inhibitors reverses fatal pulmonary arterial hypertension (PAH… 
Highly Cited
2005
Highly Cited
2005
Microanatomy of Axon/Glial Signaling during Wallerian Degeneration
How do myelinated axons signal to the nuclei of cells that enwrap them? The cell bodies of oligodendrocytes and Schwann cells are… 
Highly Cited
2004
Highly Cited
2004
HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability.
Highly Cited
2004
Highly Cited
2004
Epidermal Growth Factor Receptor Inhibition Promotes Desmosome Assembly and Strengthens Intercellular Adhesion in Squamous Cell Carcinoma Cells*
The epidermal growth factor receptor (EGFR) has been proposed as a key modulator of cadherin-containing intercellular junctions… 
Review
2003
Review
2003
Inhibitors of epidermal-growth-factor receptors: a review of clinical research with a focus on non-small-cell lung cancer.
Review
2002
Review
2002
Protein kinases as targets for anticancer agents: from inhibitors to useful drugs.
Highly Cited
2002
Highly Cited
2002
The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides.
The ErbB1 and ErbB2 receptor tyrosine kinases (RTKs) play important roles in the development of numerous types of human cancer… 
Review
2001
Review
2001
Tyrosine kinase inhibitors: From rational design to clinical trials
Protein kinases play a crucial role in signal transduction as well as in cellular proliferation, differentiation, and various… 
Highly Cited
2000
Highly Cited
2000
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma.
We determined whether down-regulation of the epidermal growth factor-receptor (EGF-R) signaling pathway by oral administration of… 
Highly Cited
1988
Highly Cited
1988
Purification of maturation-promoting factor, an intracellular regulator of early mitotic events.
Maturation-promoting factor causes germinal vesicle breakdown when injected into Xenopus oocytes and can induce metaphase in a… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)