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PKI 166

Known as: PKI-166, PKI166 
A pyrrolo-pyrimidine epidermal growth factor receptor (EGFR) protein kinase inhibitor with anti-tumor activity.PKI-166 reversibly inhibits HER1 and… Expand
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

PyrimidinesPyrroles
Receptor Tyrosine Kinase Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Epidermal Growth Factor Receptor Blockade Mediates Smooth Muscle Cell Apoptosis and Improves Survival in Rats With Pulmonary Hypertension
Background—We previously reported that administration of elastase inhibitors reverses fatal pulmonary arterial hypertension (PAH… Expand
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Highly Cited
2005
Highly Cited
2005
Microanatomy of Axon/Glial Signaling during Wallerian Degeneration
How do myelinated axons signal to the nuclei of cells that enwrap them? The cell bodies of oligodendrocytes and Schwann cells are… Expand
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Highly Cited
2004
Highly Cited
2004
Epidermal Growth Factor Receptor Inhibition Promotes Desmosome Assembly and Strengthens Intercellular Adhesion in Squamous Cell Carcinoma Cells*
The epidermal growth factor receptor (EGFR) has been proposed as a key modulator of cadherin-containing intercellular junctions… Expand
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Highly Cited
2004
Highly Cited
2004
HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability.
Given the role of the EGFR/HER2 family of tyrosine kinases in breast cancer, we dissected the molecular basis of EGFR/HER2 kinase… Expand
Highly Cited
2002
Highly Cited
2002
The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides.
The ErbB1 and ErbB2 receptor tyrosine kinases (RTKs) play important roles in the development of numerous types of human cancer… Expand
Review
2001
Review
2001
Tyrosine kinase inhibitors: From rational design to clinical trials
Protein kinases play a crucial role in signal transduction as well as in cellular proliferation, differentiation, and various… Expand
Highly Cited
2000
Highly Cited
2000
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma.
We determined whether down-regulation of the epidermal growth factor-receptor (EGF-R) signaling pathway by oral administration of… Expand
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Highly Cited
1990
Highly Cited
1990
Specificities of autoinhibitory domain peptides for four protein kinases. Implications for intact cell studies of protein kinase function.
Synthetic peptides corresponding to the autoinhibitory domains of calcium/calmodulin-dependent protein kinase II (CaMK-(281-309… Expand
Highly Cited
1989
Highly Cited
1989
Regulation of mouse preimplantation development: inhibition of synthesis of proteins in the two-cell embryo that require transcription by inhibitors of cAMP-dependent protein kinase.
Perturbing the changes in protein phosphorylation accompanying the first cleavage can inhibit the appearance of a set of proteins… Expand
Highly Cited
1988
Highly Cited
1988
Purification of maturation-promoting factor, an intracellular regulator of early mitotic events.
Maturation-promoting factor causes germinal vesicle breakdown when injected into Xenopus oocytes and can induce metaphase in a… Expand
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