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PK1 doxorubicin-HPMA conjugate
Known as:
PK1
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (3)
Doxorubicin
Polymethacrylic Acids
doxorubicin-HPMA conjugate
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer.
L. Seymour
,
D. Ferry
,
+16 authors
J. Cassidy
International Journal of Oncology
2009
Corpus ID: 18838244
Phase I studies of [N-(2-hydroxypropyl)methacrylamide] (HPMA) copolymer-doxorubicin previously showed signs of activity coupled…
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Highly Cited
2006
Highly Cited
2006
Gentamicin Causes Apoptosis at Low Concentrations in Renal LLC-PK1 Cells Subjected to Electroporation
H. Servais
,
Y. Jossin
,
F. Van Bambeke
,
P. Tulkens
,
M. Mingeot-Leclercq
Antimicrobial Agents and Chemotherapy
2006
Corpus ID: 1037591
ABSTRACT Gentamicin accumulates in the lysosomes of kidney proximal tubular cells and causes apoptosis at clinically relevant…
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Highly Cited
2004
Highly Cited
2004
Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle.
S. Battersby
,
H. Critchley
,
K. Morgan
,
R. Millar
,
H. Jabbour
Journal of Clinical Endocrinology and Metabolism
2004
Corpus ID: 36410611
This study investigated the possible role of the newly discovered endocrine gland-derived vascular endothelial growth factors and…
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Highly Cited
2001
Highly Cited
2001
Polymer-drug conjugates, PDEPT and PELT: basic principles for design and transfer from the laboratory to clinic.
R. Duncan
,
S. Gac-Breton
,
+4 authors
F. Searle
Journal of Controlled Release
2001
Corpus ID: 46039465
Highly Cited
2001
Highly Cited
2001
Cellular overexpression of heme oxygenase-1 up-regulates p21 and confers resistance to apoptosis.
P. Inguaggiato
,
L. González-Michaca
,
A. Croatt
,
J. J. Haggard
,
J. Alam
,
K. Nath
Kidney International
2001
Corpus ID: 23216859
BACKGROUND Induction of heme oxygenase-1 (HO-1) protects against diverse insults in the kidney and other tissues. We examined the…
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Highly Cited
2000
Highly Cited
2000
Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells.
Ng SSW
,
M. Tsao
,
S. Chow
,
D. Hedley
Cancer Research
2000
Corpus ID: 16169988
Human pancreatic adenocarcinoma cell lines PK1 and PK8 are resistant to the clinically relevant chemotherapy agent gemcitabine…
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Highly Cited
1999
Highly Cited
1999
Phase I Clinical and Pharmacokinetic Study of PK1 [N-(2-Hydroxypropyl)methacrylamide Copolymer Doxorubicin]: First Member of a New Class of Chemotherapeutic Agents—Drug-Polymer Conjugates
P. Vasey
,
S. Kaye
,
+11 authors
J. Cassidy
1999
Corpus ID: 73316628
PK1 comprises doxorubicin covalently bound to N -(2-hydroxypropyl)methacrylamide copolymer by a peptidyl linker. Following…
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Highly Cited
1999
Highly Cited
1999
Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer…
P. Vasey
,
S. Kaye
,
+11 authors
J. Cassidy
Clinical Cancer Research
1999
Corpus ID: 32553345
PK1 comprises doxorubicin covalently bound to N-(2-hydroxypropyl)methacrylamide copolymer by a peptidyl linker. Following…
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Highly Cited
1994
Highly Cited
1994
In vivo properties of SB 200646A, a 5‐HT2C/2B receptor antagonist
G. Kennett
,
M. Wood
,
+4 authors
T. Blackburn
British Journal of Pharmacology
1994
Corpus ID: 19899566
1 SB 200646A, N‐(1‐methyl‐5‐indolyl)‐N′‐(3‐pyridyl) urea hydrochloride, the first reported selective 5‐HT2C/2B over 5‐HT2A…
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Highly Cited
1985
Highly Cited
1985
Biochemical characterization of renal epithelial cell cultures (LLC-PK1 and MDCK).
G. Gstraunthaler
,
W. Pfaller
,
P. Kotanko
American Journal of Physiology
1985
Corpus ID: 8360914
The expression of enzymes in LLC-PK1 and MDCK cells was used to study the retention of differentiated properties of the renal…
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