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PK1 doxorubicin-HPMA conjugate

Known as: PK1 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Phase I studies of [N-(2-hydroxypropyl)methacrylamide] (HPMA) copolymer-doxorubicin previously showed signs of activity coupled… Expand
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Highly Cited
2006
Highly Cited
2006
ABSTRACT Gentamicin accumulates in the lysosomes of kidney proximal tubular cells and causes apoptosis at clinically relevant… Expand
Highly Cited
2006
Highly Cited
2006
Na(+)-taurocholate-cotransporting peptide (NTCP)/SLC10A1 and bile salt export pump (BSEP)/ABCB11 synergistically play an… Expand
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Highly Cited
2004
Highly Cited
2004
This study investigated the possible role of the newly discovered endocrine gland-derived vascular endothelial growth factors and… Expand
Highly Cited
2001
Highly Cited
2001
BACKGROUND Induction of heme oxygenase-1 (HO-1) protects against diverse insults in the kidney and other tissues. We examined the… Expand
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Highly Cited
2000
Highly Cited
2000
Human pancreatic adenocarcinoma cell lines PK1 and PK8 are resistant to the clinically relevant chemotherapy agent gemcitabine… Expand
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Highly Cited
1999
Highly Cited
1999
PK1 comprises doxorubicin covalently bound to N -(2-hydroxypropyl)methacrylamide copolymer by a peptidyl linker. Following… Expand
Highly Cited
1999
Highly Cited
1999
PK1 comprises doxorubicin covalently bound to N-(2-hydroxypropyl)methacrylamide copolymer by a peptidyl linker. Following… Expand
Highly Cited
1994
Highly Cited
1994
1 SB 200646A, N‐(1‐methyl‐5‐indolyl)‐N′‐(3‐pyridyl) urea hydrochloride, the first reported selective 5‐HT2C/2B over 5‐HT2A… Expand
Highly Cited
1985
Highly Cited
1985
The expression of enzymes in LLC-PK1 and MDCK cells was used to study the retention of differentiated properties of the renal… Expand