PK1 doxorubicin-HPMA conjugate
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Phase I studies of [N-(2-hydroxypropyl)methacrylamide] (HPMA) copolymer-doxorubicin previously showed signs of activity coupled… Expand ABSTRACT Gentamicin accumulates in the lysosomes of kidney proximal tubular cells and causes apoptosis at clinically relevant… Expand Na(+)-taurocholate-cotransporting peptide (NTCP)/SLC10A1 and bile salt export pump (BSEP)/ABCB11 synergistically play an… Expand This study investigated the possible role of the newly discovered endocrine gland-derived vascular endothelial growth factors and… Expand BACKGROUND
Induction of heme oxygenase-1 (HO-1) protects against diverse insults in the kidney and other tissues. We examined the… Expand Human pancreatic adenocarcinoma cell lines PK1 and PK8 are resistant to the clinically relevant chemotherapy agent gemcitabine… Expand PK1 comprises doxorubicin covalently bound to N -(2-hydroxypropyl)methacrylamide copolymer by a peptidyl linker. Following… Expand PK1 comprises doxorubicin covalently bound to N-(2-hydroxypropyl)methacrylamide copolymer by a peptidyl linker. Following… Expand 1 SB 200646A, N‐(1‐methyl‐5‐indolyl)‐N′‐(3‐pyridyl) urea hydrochloride, the first reported selective 5‐HT2C/2B over 5‐HT2A… Expand The expression of enzymes in LLC-PK1 and MDCK cells was used to study the retention of differentiated properties of the renal… Expand