PITUITARY ANOMALIES WITH HOLOPROSENCEPHALY-LIKE FEATURES (disorder)
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Solitary median maxillary central incisor (SMMCI) is a rare dental anomaly characterized by a symmetric central incisor of normal… Expand Six3 exerts multiple functions in the development of anterior neural tissue of vertebrate embryos. Whereas complete loss of Six3… Expand Variation is an intrinsic feature of biological systems, yet developmental biology does not frequently address population-level… Expand BACKGROUND
The Hedgehog (Hh) pathway provides inductive signals critical for developmental patterning of the brain and face. In… Expand Holoprosencephaly (HPE) is the most common human congenital forebrain defect, affecting specification of forebrain tissue and… Expand The putative transcription factor ZIC2 is associated with a defect of forebrain development, known as Holoprosencephaly (HPE), in… Expand Mutations of the developmental gene Sonic hedgehog (SHH) and alterations of SHH signaling have been associated with… Expand Holoprosencephaly (HPE) is a condition characterized by a defect in the development of the midline embryonic forebrain. When… Expand The homeodomain protein TGIF represses transcription in part by recruiting histone deacetylases. TGIF binds directly to DNA to… Expand