FAQ

PICALM/MLLT10 Fusion Protein

Known as: PICALM-AF10 Fusion Protein, Phosphatidylinositol-Binding Clathrin Assembly Protein/Protein AF-10 Fusion Protein PICALM/AF10 Fusion Protein, CALM/AF10 Fusion Protein 
A fusion protein encoded by the PICALM/MLLT10 fusion gene. This protein is comprised of all but the last 4 amino acids of the phosphatidylinositol… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2003-2018
012320032018

Related topics

Related topics

2 relations
Fusion GenePICALM/AF10 FUSION GENE

Related mentions per year

Related mentions per year

1983-2018
19801990200020102020
PICALM/MLLT10 Fusion Protein
Fusion Gene
PICALM/AF10 FUSION GENE

Papers overview

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2018
2018
Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
The mixed-lineage leukemia (MLL)-AF10 fusion oncoprotein recruits DOT1L to the homeobox A (HOXA) gene cluster through its… (More)
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2016
2016
Impact of PICALM and CLU on hippocampal degeneration.
PICALM and CLU are two major risk genes of late-onset Alzheimer's disease (LOAD), and there is strong molecular evidence… (More)
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2015
2015
Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease.
We tested association of nine late-onset Alzheimer's disease (LOAD) risk variants from genome-wide association studies (GWAS… (More)
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2014
2014
Genetic Evidence for the Involvement of Variants at APOE, BIN1, CR1, and PICALM Loci in Risk of Late-Onset Alzheimer’s Disease and Evaluation for Interactions with APOE Genotypes
Alzheimer’s disease (AD) is the most common form of dementia in older population. Growing evidence of genetic background that… (More)
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2014
2014
Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial
The traditional Mediterranean diet (MedDiet) has shown beneficial effects on cognitive decline. Nevertheless, diet–gene… (More)
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2014
2014
Cryptic XPO1-MLLT10 translocation is associated with HOXA locus deregulation in T-ALL.
Biological subclasses of T-cell acute lymphoblastic leukemia (T-ALL) can be defined by recurrent gene expression patterns, which… (More)
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2013
2013
Detection of PICALM-MLLT10 (CALM-AF10) and outcome in children with T-lineage acute lymphoblastic leukemia
case-control studies of childhood diseases. Am J Epidemiol 2004; 159: 915–921. 8 Aldrich MC, Zhang L, Wiemels JL, Ma X, Loh ML… (More)
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2012
2012
PICALM-MLLT10 acute myeloid leukemia: a French cohort of 18 patients.
The PICALM-MLLT10 fusion gene, generated by the t(10;11)(p12-13;q14-21) translocation, is a rare but recurrent event in acute… (More)
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2006
2006
Acute monocytic leukemia with coexpression of minor BCR-ABL1 and PICALM-MLLT10 fusion genes along with overexpression of HOXA9.
The t(9;22)(q34;q11) translocation occurs in chronic myeloid leukemia (CML) and adult B-cell acute lymphoblastic leukemia (ALL… (More)
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Highly Cited
2003
Highly Cited
2003
CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRgammadelta lineage.
The t(10;11)(p13-14;q14-21) associated with CALM-AF10 is considered to be rare and associated with a variety of acute lymphoid… (More)
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