PI3K Inhibitor GDC-0941 Bismesylate

Known as: 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1- ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, bimesylate salt, GDC-0941 Bismesylate 
The orally bioavailable bismesylate salt of a potent small-molecule thieno[3,2-d]pyrimidine inhibitor of the class I phosphatidylinositol 3 kinase… (More)
National Institutes of Health

Papers overview

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2014
2014
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, and the limited available treatment options have… (More)
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Review
2012
Review
2012
Tumor inflammatory microenvironment is considered to play the role in the sensitivity of tumor cells to therapies and prognosis… (More)
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2012
2012
A series of thieno[3,2-d]pyrimidines incorporated with a piperazine unit as putative anti-cancer agents were designed and… (More)
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2011
2011
3005^ Background: The RAS/RAF/MEK and PI3K/AKT signaling pathways are both deregulated in many tumor types. Targeting both… (More)
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2011
2011
Lung cancer is a malignant disease with poor outcome, which has led to a search for new therapeutics. The PI3K/Akt/mTOR and Ras… (More)
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2010
2010
The phosphatidylinositol 3-kinase (PI3K) pathway is a major determinant of cell cycling and proliferation. Its deregulation, by… (More)
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2010
2010
2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) is a novel… (More)
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Highly Cited
2008
Highly Cited
2008
Phosphatidylinositol-3-kinase (PI3K) is an important target in cancer due to the deregulation of the PI3K/ Akt signaling pathway… (More)
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1993
1993
Earlier we synthesized derivatives of 3-cyano-4-aminopyridine-2-thiones, based on which, using the thorpe-Ziegler reaction, we… (More)
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