Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

PI3K/mTOR Inhibitor LY3023414

Known as: LY 3023414, LY-3023414, LY3023414 
An orally bioavailable, small molecule inhibitor of certain class I phosphoinositide 3-kinase (PI3K) isoforms and mammalian target of rapamycin… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
HGSOC (characterized by defects in DNA damage repair and high levels of genomic instability and DNA replication stress) is the… Expand
Is this relevant?
2018
2018
Purpose: The PI3K/mTOR pathway is frequently aberrated in cancer. LY3023414 is a potent and selective ATP-competitive inhibitor… Expand
Is this relevant?
Review
2017
Review
2017
Prostate cancer is a leading cause of cancer-related death in men worldwide. Aberrant signaling in the androgen pathway is… Expand
  • figure 1
  • table 1
Is this relevant?
2017
2017
Objective: The purpose of the current study is to determine the efficacy of a PI3K/mTOR dual inhibitor, LY3023414, on established… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2017
2017
Therapeutic targeting of the PI3K pathway is an active area of research in multiple cancer types, including breast and… Expand
Is this relevant?
2017
2017
Abnormal activation of PI3K-AKT-mTOR signaling is detected in human skin squamous cell carcinoma (SCC). LY3023414 is a novel… Expand
Is this relevant?
2016
2016
The PI3K/AKT/mTOR pathway is among the most frequently altered pathways in cancer cell growth and survival. LY3023414 is a… Expand
  • table 1
  • table 2
  • table 3
  • table 4
  • table 5
Is this relevant?
2016
2016
PURPOSE Effective systemic therapeutic options are limited for bladder cancer. In this preclinical study we tested whether… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2016
2016
Therapeutic targeting of the phosphoinositide 3-kinase (PI3K) pathway is an active area of research in multiple cancer types… Expand
Is this relevant?
2015
2015
11075 Background: The phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway is dysregulated in many… Expand
Is this relevant?