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PHA 767491

Known as: PHA-767491, PHA767491 
National Institutes of Health

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2 relations

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PiperidonesPyrroles

Papers overview

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2019
2019
Generation of strong casein kinase 1 inhibitor of Arabidopsis thaliana
Casein kinase 1 (CK1) is an evolutionarily conserved protein kinase among eukaryotes. Studies on yeast, fungi, and animals have… 
2018
2018
Abstract 1632: Suppression of EWS-FLI1 transcription using a combination therapy of mithramycin and cyclin-dependent kinase 9 inhibition
Background: Ewing sarcoma (ES) is a pediatric soft tissue tumor with a poor prognosis. ES is dependent on the presence and… 
2017
2017
Abstract 103: Blockage of Cdc7/CDK9 signaling sensitizes triple negative breast cancer to EGFR-targeted therapy
The treatment of Triple-Negative Breast Cancer (TNBC) still represents a profound clinical challenge, the disease being… 
2016
2016
Down-regulating cyclin-dependent kinase 9 of alloreactive CD4+ T cells prolongs allograft survival
CDK9 (Cyclin-dependent kinase 9)/Cyclin T1/RNA polymerase II pathway has been demonstrated to promote the development of several… 
2010
2010
The BH3 Mimetic, ABT-737, Overcomes Stromal-Mediated Pro-Survival Signals and Synergizes with PHA-767491, a Dual Cdc7/CDK9 Inhibitor, In Acute Myeloid Leukaemia
Abstract 1841 ABT-737 is a small molecule inhibitor of Bcl-2 and Bcl-xL with reported activity in pre-clinical in-vitro and in… 
2010
2010
PHA-767491 Inhibits Growth of Tumor Cells in Culture
Cdc7 kinase inhibitor PHA-767491 is a novel antitumor agent. This study aims to examine the antitumor activity of PHA-767491… 
2010
2010
Study of the Anti-Tumor Efficacy by PHA-767491 Combined with IL-24 in Hepatocellular Carcinoma Cells
New anti-tumor medicine PHA-767491 is used to kill tumor cells combined with IL-24.Here the authors demonstrate that 20 MOI of… 
2009
2009
PHA767491, a Dual Cdc7/CDK9 Inhibitor, with Potential to Target Both Proliferation and Survival in CLL.
Abstract 2366 Poster Board II-343 CLL is characterized by a combination of a block in apoptosis allied to the steady expansion of… 
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