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PHA 739358
Known as:
PHA-739358
, PHA739358
A small synthetic molecule with potential antitumor activity. PHA-739358 inhibits catalytic activity of Aurora kinases, a family of serine-threonine…
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National Institutes of Health
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Broader (1)
danusertib
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Wirkung des Aurorakinaseinhibitors Danusertib (PHA-739358) auf nichtseminomatöse Keimzelltumorlinien
Juliane Waskow
2015
Corpus ID: 94175701
Cisplatin gilt als Therapiestandard bei der Behandlung von Keimzelltumoren. Die erreichten signifikanten Heilungsraten von uber…
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2012
2012
Neuroendocrine Tumors in an Orthotopic Xenograft Model Growth of Liver Metastases from Gastroenteropancreatic Targeting Aurora Kinases with Danusertib (PHA-739358) Inhibits
K. Fraedrich
,
H. Ittrich
2012
Corpus ID: 79484711
Purpose: Aurora kinases play a crucial role in cell-cycle control. Uncontrolled expression of aurora kinases causes aneuploidy…
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2012
2012
Die Bedeutung der Bcr-Abl und Aurora Kinase Inhibition für die biologische Aktivität der dualen Inhibitoren PHA-739358 und AS-703569 in Bcr-Abl transformierten Zellen
A. Seitz
2012
Corpus ID: 104284349
Der Tyrosinkinaseinhibitor (TKI) Imatinib ist der Goldstandard in der Therapie der Bcr-Abl positiven chronisch myeloischen…
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2010
2010
Therapeutics , Targets , and Chemical Biology Preclinical Evaluation of AMG 900 , a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines
Marc Payton
,
T. Bush
,
+18 authors
R. Kendall
2010
Corpus ID: 13032760
In mammalian cells, the aurora kinases (aurora-A, -B, and -C) play essential roles in regulating cell division. The expression of…
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2009
2009
Administered as a 24-Hour Infusion with and without Granulocyte Colony-Stimulating Factor in a 14-Day Cycle in Patients with Advanced Solid Tumors
R. Cohen
,
S. Jones
,
+11 authors
H. Burris
2009
Corpus ID: 34625916
Purpose: This study was conducted to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of the i.v. pan…
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2009
2009
Durchführung und Analyse einer Phase I-Studie mit einem Aurorakinaseinhibitor zur Therapie akuter Leukämien
Katharina Taktikos
2009
Corpus ID: 53935134
Die Arbeit begutachtet den Ablauf einer Phase I-Studie mit dem Aurorakinaseinhibitor PHA-739358 bei Patienten mit akuten…
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2008
2008
Targeted therapies in cancer: myth or reality? Introduction.
F. Colotta
,
A. Mantovani
Advances in Experimental Medicine and Biology
2008
Corpus ID: 68747700
Causality in Medicine.- The Evolution of the Biomedical Paradigm in Oncology: Implications for Cancer Therapy.- Anticancer Drug…
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2008
2008
Gateways to clinical trials.
A. Tomillero
,
M. A. Moral
Methods and Findings in Experimental and Clinical…
2008
Corpus ID: 26153196
Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data in the…
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2008
2008
Gateways to clinical trials.
A. Tomillero
,
M. A. Moral
Methods and Findings in Experimental and Clinical…
2008
Corpus ID: 38287257
(-)-Epigallocatechin gallate, (-)-Gossypol; Ad.hIFN-beta, AF-37702, Agatolimod sodium, Agomelatine, Alvocidib hydrochloride, ARC…
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