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PHA 408

Known as: PHA-408, PHA408 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

IndazolesIsonicotinic Acids

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Essential role of STAT-3 dependent NF-κB activation on IL-6-mediated downregulation of hepatic transporters.
Highly Cited
2017
Highly Cited
2017
Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin
Cellular senescence is characterized by a permanent cell-cycle arrest and a pro-inflammatory secretory phenotype, and can be… 
2017
2017
Involvement of Nuclear Factor κB, not Pregnane X Receptor, in Inflammation-Mediated Regulation of Hepatic Transporters
Endotoxin-induced inflammation decreases the hepatic expression of several drug transporters, metabolizing enzymes, and nuclear… 
Review
2017
Review
2017
Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation
Psoriasis is a chronic inflammatory autoimmune disease that can be initiated by excessive activation of endosomal toll-like… 
2015
2015
The effect of specific IKKβ inhibitors on the cytosolic expression of IκB-α and the nuclear expression of p65 in dystrophic (MDX) muscle.
The efficacy of two highly specific IκB-α kinase β (IKK-β) inhibitors in reducing the enhanced basal activation of the NF-κB… 
Review
2013
Review
2013
Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases.
2010
2010
Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke.
2010
2010
Expression, purification and functional characterization of IkappaB kinase-2 (IKK-2) mutants.
Highly Cited
2009
Highly Cited
2009
A Novel, Highly Selective, Tight Binding IκB Kinase-2 (IKK-2) Inhibitor: A Tool to Correlate IKK-2 Activity to the Fate and Functions of the Components of the Nuclear Factor-κB Pathway in Arthritis…
Nuclear factor (NF)-κB activation has been clearly linked to the pathogenesis of multiple inflammatory diseases including… 
2009
2009
Novel Tight-Binding Inhibitory Factor-κB Kinase (IKK-2) Inhibitors Demonstrate Target-Specific Anti-Inflammatory Activities in Cellular Assays and following Oral and Local Delivery in an in Vivo…
Nuclear factor-κB (NF-κB) is one of the major families of transcription factors activated during the inflammatory response in… 
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