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PF 04217903

Known as: MET Tyrosine Kinase Inhibitor PF-04217903, PF-04217903, PF04217903 
An orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic activity. MET tyrosine kinase inhibitor PF-04217903… Expand
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Oncogenic gene fusions have been identified in many cancers and many serve as biomarkers or targets for therapy. Here we identify… Expand
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2013
2013
Epithelial ovarian cancer (EOC) metastasizes transcoelomically to the peritoneum and omentum, and despite surgery and… Expand
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2013
2013
Inhibition of VEGF signaling can promote lymph node metastasis in preclinical models, but the mechanism is not fully understood… Expand
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Highly Cited
2012
Highly Cited
2012
UNLABELLED Invasion and metastasis increase after the inhibition of VEGF signaling in some preclinical tumor models. In the… Expand
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2012
2012
The c-Met pathway has been implicated in a variety of human cancers for its critical role in tumor growth, invasion, and… Expand
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2012
2012
The c-MET receptor tyrosine kinase is an attractive oncology target because of its critical role in human oncogenesis and tumor… Expand
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2012
2012
Targeting cancers with amplified or abnormally activated c-Met (hepatocyte growth factor receptor) may have therapeutic benefit… Expand
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2011
2011
The objective of this study was to assess the physiologically based pharmacokinetic (PBPK) model for predicting plasma… Expand
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2010
2010
9567 Background: MET is a tyrosine kinase receptor that is important for normal cell growth and migration. Activating alterations… Expand
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Highly Cited
2009
Highly Cited
2009
The c-Met receptor tyrosine kinase (RTK) is a key regulator in cancer, in part, through oncogenic mutations. Eight clinically… Expand
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