PDK1 Inhibitor AR-12

Known as: AR-12 
An orally bioavailable, small-molecule, celecoxib-derived inhibitor of phosphoinositide-dependent kinase-1 (PDK1) with potential antineoplastic… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2009-2016
024620092016

Papers overview

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2016
2016
We performed proteomic studies using the GRP78 chaperone-inhibitor drug AR-12 (OSU-03012) as bait. Multiple additional chaperone… (More)
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2016
2016
Only one new class of antifungal drugs has been introduced into clinical practice in the last 30 years, and thus the… (More)
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2015
2015
We examined the interaction between OSU-03012 (also called AR-12) with phosphodiesterase 5 (PDE5) inhibitors to determine the… (More)
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2015
2015
The chaperone GRP78/Dna K is conserved throughout evolution down to prokaryotes. The GRP78 inhibitor OSU-03012 (AR-12) interacted… (More)
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2014
2014
Autophagy is a lysosomal degradative process essential for neuronal homeostasis, whereas autophagic failure has been linked to… (More)
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2013
2013
Meningiomas constitute about 34% of primary intracranial tumors and are associated with increased mortality in patients with… (More)
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2012
2012
G-protein-coupled receptors (GPCR) activate the epidermal growth factor receptor (EGFR) and mediate EGFR-independent signaling… (More)
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2010
2010
The present studies focused on determining whether the autophagy-inducing drug OSU-03012 (AR-12) could enhance the toxicity of… (More)
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2009
2009
Autophagy has been shown recently to play an important role in the intracellular survival of several pathogenic bacteria. In this… (More)
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2009
2009
Eradication of intracellular pathogenic bacteria with host-directed chemical agents has been an anticipated innovation in the… (More)
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