FAQ

PDE4C gene

Known as: PDE4C, PHOSPHODIESTERASE 4C, cAMP-SPECIFIC, phosphodiesterase E1 dunce homolog (Drosophila) 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2018
024619952018

Papers overview

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Highly Cited
2013
Highly Cited
2013
Aging of blood can be tracked by DNA methylation changes at just three CpG sites
Human aging is associated with DNA methylation changes at specific sites in the genome. These epigenetic modifications may be… (More)
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2012
2012
Disease Progression in MRL/lpr Lupus-Prone Mice Is Reduced by NCS 613, a Specific Cyclic Nucleotide Phosphodiesterase Type 4 (PDE4) Inhibitor
Systemic lupus erythematosus is a polymorphic and multigenic inflammatory autoimmune disease. Cyclic AMP (cAMP) modulates… (More)
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2011
2011
NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues.
Chronic inflammation is a hallmark of pulmonary diseases, which leads to lung parenchyma destruction (emphysema) and obstructive… (More)
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Highly Cited
2005
Highly Cited
2005
Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue.
Cyclic nucleotide PDE4 (phosphodiesterase 4) inhibitors are being developed as potent anti-inflammatory drugs for use in chronic… (More)
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2005
2005
Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells.
Cyclic adenosine monophosphate (cAMP) is an important second messenger in the hormonal regulation of bone metabolism. cAMP is… (More)
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2004
2004
Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells.
Monocytes and macrophages provide key targets for the action of novel anti-inflammatory therapeutics targeted at inhibition of… (More)
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2001
2001
Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey.
Pre-clinical and clinical studies are currently underway to evaluate the potential of phosphodiesterase-4 (PDE4) inhibitors for… (More)
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2001
2001
Expression of different phosphodiesterase genes in human cavernous smooth muscle.
PURPOSE Knowledge of intracellular signal propagation in smooth muscle tone regulation is of major importance in the… (More)
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Highly Cited
2000
Highly Cited
2000
Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain.
We have examined the distribution of four different cyclic AMP-specific phosphodiesterase isozyme (PDE4A, PDE4B, PDE4C and PDE4D… (More)
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1995
1995
Salbutamol up-regulates PDE4 activity and induces a heterologous desensitization of U937 cells to prostaglandin E2. Implications for the therapeutic use of beta-adrenoceptor agonists.
Previous studies with U937 cells, a human monocyte cell line, have shown that the activity of cyclic nucleotide phosphodiesterase… (More)
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