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PDE2A gene

Known as: PDE2A, Phosphodiesterase 2A, cGMP-Stimulated Gene, PHOSPHODIESTERASE 2A, cGMP-STIMULATED 
This gene is involved in second messenger molecule metabolism.
National Institutes of Health

Related topics

Related topics

4 relations
Cyclic Nucleotide Phosphodiesterases, Type 2AHydrolysisNucleotide MetabolismSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network (“Rhesactome”) in the striatum
Protein interaction networks of the GTPase Rhes regulate motor control in the striatum. Rhes networks in motor control Drugs like… 
2014
2014
Phosphodiesterase 2A Localized in the Spinal Cord Contributes to Inflammatory Pain Processing
Background:Phosphodiesterase 2A (PDE2A) is an evolutionarily conserved enzyme that catalyzes the degradation of the cyclic… 
Highly Cited
2013
Highly Cited
2013
Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A.
2012
2012
Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity
The heart peptide hormone atrial natriuretic peptide (ANP) regulates blood pressure by stimulating guanylyl cyclase-A to produce… 
2011
2011
Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury.
Phosphodiesterase 2A (PDE2A) is stimulated by cGMP to hydrolyze cAMP, a potent endothelial barrier-protective molecule. We… 
Highly Cited
2009
Highly Cited
2009
Dual Acylation of PDE2A Splice Variant 3
The cGMP-stimulated PDE2A hydrolyzes both cyclic nucleotides, cGMP and cAMP. Three splice variants have been cloned from several… 
2009
2009
Determination of the structure of human phosphodiesterase-2 in a bound state and its binding with inhibitors by molecular modeling, docking, and dynamics simulation.
Although an X-ray crystal structure of the catalytic domain of human cyclic nucleotide phosphodiesterase-2 (PDE2A) was reported… 
Review
2007
Review
2007
Sodium regulation of GAF domain function.
Cyclic nucleotide PDEs (phosphodiesterases) regulate cellular levels of cAMP and cGMP by controlling the rate of degradation… 
2007
2007
Phosphodiesterase 2 A Forms a Complex with the Co-chaperone XAP 2 and Regulates Nuclear Translocation of the Aryl Hydrocarbon Receptor *
Simone Kobe de Oliveira, Meike Hoffmeister, Stepan Gambaryan , Werner Müller-Esterl, Jorge A. Guimaraes, and Albert P. Smolenski… 
2003
2003
Modeling and mutational analysis of the GAF domain of the cGMP‐binding, cGMP‐specific phosphodiesterase, PDE5
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