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PDE2A gene

Known as: PDE2A, Phosphodiesterase 2A, cGMP-Stimulated Gene, PHOSPHODIESTERASE 2A, cGMP-STIMULATED 
This gene is involved in second messenger molecule metabolism.
National Institutes of Health

Related topics

Related topics

4 relations
Cyclic Nucleotide Phosphodiesterases, Type 2AHydrolysisNucleotide MetabolismSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
First-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430.
UNLABELLED This was a first-in-human study of the novel phosphodiesterase-2A (PDE2A) PET ligand (18)F-PF-05270430. The primary… Expand
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2013
2013
Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A.
Although hydrogen sulfide (H₂S) is generally known as a mitochondrial poison, recent studies show that lower concentrations of H… Expand
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Highly Cited
2012
Highly Cited
2012
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation. We report a meta-analysis of genome… Expand
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2012
2012
Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity.
The heart peptide hormone atrial natriuretic peptide (ANP) regulates blood pressure by stimulating guanylyl cyclase-A to produce… Expand
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2009
2009
Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes.
The cGMP-stimulated PDE2A hydrolyzes both cyclic nucleotides, cGMP and cAMP. Three splice variants have been cloned from several… Expand
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2008
2008
Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice.
High tidal volume (HV(T)) ventilation causes pulmonary endothelial barrier dysfunction. HV(T) ventilation also increases lung… Expand
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Highly Cited
2007
Highly Cited
2007
Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3.
Endothelial barrier dysfunction leading to increased permeability and vascular leakage is an underlying cause of several… Expand
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2004
2004
Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase…
The cytokines macrophage colony-stimulating factor (M-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) promote… Expand
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2002
2002
Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases.
Platelets contain two cAMP phosphodiesterases (PDEs) which regulate intracellular cAMP levels, cGMP-inhibited cAMP PDE (PDE3A… Expand
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1999
1999
Differential Expression of the Cyclic GMP-stimulated Phosphodiesterase PDE2A in Human Venous and Capillary Endothelial Cells
We developed selective monoclonal antibodies and used them for Western and immunocytochemical analyses to determine the tissue… Expand
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