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PDE2A gene
Known as:
PDE2A
, Phosphodiesterase 2A, cGMP-Stimulated Gene
, PHOSPHODIESTERASE 2A, cGMP-STIMULATED
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This gene is involved in second messenger molecule metabolism.
National Institutes of Health
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Related topics
Related topics
4 relations
Cyclic Nucleotide Phosphodiesterases, Type 2A
Hydrolysis
Nucleotide Metabolism
Signal Transduction
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain.
M. Kelly
,
W. Adamowicz
,
+6 authors
R. Kleiman
Cellular Signalling
2014
Corpus ID: 206581935
Highly Cited
2013
Highly Cited
2013
Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A.
Katalin Módis
,
P. Panopoulos
,
C. Coletta
,
A. Papapetropoulos
,
C. Szabó
Biochemical Pharmacology
2013
Corpus ID: 24433631
Highly Cited
2012
Highly Cited
2012
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
Y. Okada
,
C. Terao
,
+48 authors
Kazuhiko Yamamoto
Nature Genetics
2012
Corpus ID: 205345424
Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation. We report a meta-analysis of genome…
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Highly Cited
2011
Highly Cited
2011
A Phosphodiesterase 2A Isoform Localized to Mitochondria Regulates Respiration*
R. Acín-Pérez
,
M. Russwurm
,
+8 authors
C. Steegborn
Journal of Biological Chemistry
2011
Corpus ID: 43906618
Mitochondria are central organelles in cellular energy metabolism, apoptosis, and aging processes. A signaling network regulating…
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Highly Cited
2010
Highly Cited
2010
PDE5A suppression of acute β-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation
Dong I. Lee
,
S. Vahebi
,
+4 authors
D. Kass
Basic Research in Cardiology
2010
Corpus ID: 12421888
Phosphodiesterase type 5A (PDE5A) inhibitors acutely suppress beta-adrenergic receptor (β-AR) stimulation in left ventricular…
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Highly Cited
2009
Highly Cited
2009
Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct
J. Pandit
,
M. D. Forman
,
K. Fennell
,
K. Dillman
,
F. Menniti
Proceedings of the National Academy of Sciences
2009
Corpus ID: 22927729
We report the X-ray crystal structure of a phosphodiesterase (PDE) that includes both catalytic and regulatory domains. PDE2A…
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Review
2009
Review
2009
Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights.
C. C. Heikaus
,
J. Pandit
,
R. Klevit
Structure
2009
Corpus ID: 6569225
Highly Cited
2007
Highly Cited
2007
Differential Regulation of Endothelial Cell Permeability by cGMP via Phosphodiesterases 2 and 3
J. Surapisitchat
,
K. Jeon
,
C. Yan
,
J. Beavo
Circulation Research
2007
Corpus ID: 6702487
Increased endothelial permeability is an underlying cause of several pathological conditions. While cAMP decreases endothelial…
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Highly Cited
2006
Highly Cited
2006
Immunohistochemical Localization of Phosphodiesterase 2A in Multiple Mammalian Species
D. Stephenson
,
T. Coskran
,
+6 authors
D. Morton
Journal of Histochemistry and Cytochemistry
2006
Corpus ID: 17663592
Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that…
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Highly Cited
2004
Highly Cited
2004
Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase…
A. Bender
,
Cari L Ostenson
,
D. Giordano
,
J. Beavo
Cellular Signalling
2004
Corpus ID: 20506840
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