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PDE2A gene

Known as: PDE2A, Phosphodiesterase 2A, cGMP-Stimulated Gene, PHOSPHODIESTERASE 2A, cGMP-STIMULATED 
This gene is involved in second messenger molecule metabolism.
National Institutes of Health

Related topics

Related topics

4 relations
Cyclic Nucleotide Phosphodiesterases, Type 2AHydrolysisNucleotide MetabolismSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain.
Highly Cited
2013
Highly Cited
2013
Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A.
Highly Cited
2012
Highly Cited
2012
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation. We report a meta-analysis of genome… 
Highly Cited
2011
Highly Cited
2011
A Phosphodiesterase 2A Isoform Localized to Mitochondria Regulates Respiration*
Mitochondria are central organelles in cellular energy metabolism, apoptosis, and aging processes. A signaling network regulating… 
Highly Cited
2010
Highly Cited
2010
PDE5A suppression of acute β-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation
Phosphodiesterase type 5A (PDE5A) inhibitors acutely suppress beta-adrenergic receptor (β-AR) stimulation in left ventricular… 
Highly Cited
2009
Highly Cited
2009
Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct
We report the X-ray crystal structure of a phosphodiesterase (PDE) that includes both catalytic and regulatory domains. PDE2A… 
Review
2009
Review
2009
Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights.
Highly Cited
2007
Highly Cited
2007
Differential Regulation of Endothelial Cell Permeability by cGMP via Phosphodiesterases 2 and 3
Increased endothelial permeability is an underlying cause of several pathological conditions. While cAMP decreases endothelial… 
Highly Cited
2006
Highly Cited
2006
Immunohistochemical Localization of Phosphodiesterase 2A in Multiple Mammalian Species
Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that… 
Highly Cited
2004
Highly Cited
2004
Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase…
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