FAQ

PDE2A gene

Known as: PDE2A, Phosphodiesterase 2A, cGMP-Stimulated Gene, PHOSPHODIESTERASE 2A, cGMP-STIMULATED 
This gene is involved in second messenger molecule metabolism.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
051019972017

Related topics

Related topics

4 relations
Cyclic Nucleotide Phosphodiesterases, Type 2AHydrolysisNucleotide MetabolismSignal Transduction

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
PDE2A gene
Signal Transduction
Nucleotide Metabolism
Hydrolysis
Cyclic Nucleotide Phosphodiesterases, Type 2A

Papers overview

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2013
2013
Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A.
Although hydrogen sulfide (H₂S) is generally known as a mitochondrial poison, recent studies show that lower concentrations of H… (More)
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Highly Cited
2012
Highly Cited
2012
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation. We report a meta-analysis of genome… (More)
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2010
2010
Nitric oxide signaling via cGMP-stimulated phosphodiesterase in striatal neurons.
Nitric oxide (NO) acts in the nervous system to activate guanylyl cyclase and increase cGMP. One target for cGMP appears to be… (More)
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2009
2009
Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes.
The cGMP-stimulated PDE2A hydrolyzes both cyclic nucleotides, cGMP and cAMP. Three splice variants have been cloned from several… (More)
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2008
2008
Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice.
High tidal volume (HV(T)) ventilation causes pulmonary endothelial barrier dysfunction. HV(T) ventilation also increases lung… (More)
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2007
2007
Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3.
Endothelial barrier dysfunction leading to increased permeability and vascular leakage is an underlying cause of several… (More)
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2005
2005
Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system.
Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac contractility, platelet… (More)
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2004
2004
Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase…
The cytokines macrophage colony-stimulating factor (M-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) promote… (More)
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2001
2001
Expression of different phosphodiesterase genes in human cavernous smooth muscle.
PURPOSE Knowledge of intracellular signal propagation in smooth muscle tone regulation is of major importance in the… (More)
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1999
1999
Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells.
We developed selective monoclonal antibodies and used them for Western and immunocytochemical analyses to determine the tissue… (More)
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