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PD 145065

Known as: PD-145065, PD145065 
National Institutes of Health

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1 relation

Broader (1)

Oligopeptides

Papers overview

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2014
2014
Cocaine Constriction of Rat Basilar Artery in situ: Roles of Nitric Oxide and Endothelin-1
This study investigated whether cocaine constriction of rat basilar artery in situ is mediated by nitric oxide (NO) inhibition… 
1998
1998
Distinct endothelin-B receptors mediate the effects of sarafotoxin S6c and IRL1620 in the ileum.
In the guinea pig ileum, both sarafotoxin S6c (S6c) and IRL1620 induced a biphasic effect (relaxation and contraction). S6c… 
Highly Cited
1997
Highly Cited
1997
Design of a potent combined pseudopeptide endothelin-A/endothelin-B receptor antagonist, Ac-DBhg16-Leu-Asp-Ile-[NMe]Ile-Trp21 (PD 156252): examination of its pharmacokinetic and spectral properties.
The endothelins (ETs) are a family of bicyclic 21-amino acid peptides that are potent and prolonged vasoconstrictors. It has been… 
1997
1997
Cardiovascular and renal effects of endothelin receptor blockade with PD 145065 and interaction with urodilatin.
Role of endogenous endothelins (ET) in the control of cardiovascular system and renal function, and ET interaction with… 
Highly Cited
1996
Highly Cited
1996
Acute hypertension after nitric oxide synthase inhibition is mediated primarily by increased endothelin vasoconstriction
Objective To determine the quantitative roles played by the different vasoconstrictor systems in the acute pressor response in… 
1996
1996
Distribution of endothelin-1-receptor subtypes in rat portal vein.
Endothelin-1 (ET-1), a potent vasoactive peptide, was first isolated from cultured porcine endothelial cells. Subsequent studies… 
1995
1995
Inhibition of ETB Receptors Limits the Efficacy of Nonselective Endothelin Antagonists In Vivo
Summary: Endothelin-1 (ET-1) produces vasoconstriction via activation of ETA and ETB receptors on vascular smooth muscle, and… 
1995
1995
Effects of ET antagonists (PD143296 and PD145065) on contractions in guinea pig hilar bronchus induced by endothelin-1 and its related peptide.
ETs-induced contractions were resistant to ET(A)-selective antagonists and believed to be mediated by activation of ETB receptors… 
1994
1994
Characterization of endothelin (ET) receptors in the isolated gall bladder of the guinea‐pig: evidence for an additional ET receptor subtype
1 We have characterized the receptors mediating contractions induced by endothelin‐1 (ET‐1), ET‐2, ET‐3 and the ETB‐selective… 
1993
1993
Heterogeneous receptors mediate endothelin-1-induced changes in blood pressure, hematocrit, and platelet aggregation.
Using selective endothelin (ET) receptor antagonists, we investigated which ET receptor subtypes mediate the changes in blood… 
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