PARP-1/2 Inhibitor ABT-767
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Poly(ADP-ribose) polymerase (PARP) inhibitors have shown substantial activity in homologous recombination- (HR… Expand Citation for published version (APA): van der Biessen, D. A. J., Gietema, J. A., de Jonge, M. J. A., Desar, I. M. E., den… Expand SummaryPurpose This phase 1 study examined safety, pharmacokinetics (PK), and efficacy of the poly(ADP-ribose) polymerase (PARP… Expand PurposeThe objective of the manuscript is to describe the development of a population pharmacokinetic model for ABT-767, a potent… Expand BACKGROUND: Malignancies with homologous repair deficiency (HRD) are more dependent on PARP for DNA repair than normal cells… Expand ABSTRACT Background: ABT-767 is a potent oral inhibitor of PARP-1 and -2. Malignancies with defects in homologous repair are more… Expand