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PARN, 1-BP INS, 563T

National Institutes of Health

Papers overview

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2019
2019
From incomplete penetrance with normal telomere length to severe disease and telomere shortening in a family with monoallelic and biallelic PARN pathogenic variants
PARN encodes poly(A)‐specific ribonuclease. Biallelic and monoallelic PARN variants are associated with Hoyeraal‐Hreidarsson… 
2018
2018
Nucleolin phosphorylation regulates PARN deadenylase activity during cellular stress response
ABSTRACT Nucleolin (NCL) is an abundant stress-responsive, RNA-binding phosphoprotein that controls gene expression by regulating… 
2016
2016
A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells
ABSTRACT The removal of mRNA transcript poly(A) tails by 3′→5′ exonucleases is the rate-limiting step in mRNA decay in eukaryotes… 
2015
2015
PARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells
mRNA deadenylation is under the control of cis-acting regulatory elements, which include AU-rich elements (AREs) and microRNA… 
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