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Cell polarity is critical for epithelial structure and function. Adherens junctions (AJs) often direct this polarity, but we… Expand During convergent extension in Drosophila, polarized cell movements cause the germband to narrow along the dorsal-ventral (D-V… Expand Several protein complexes that are involved in epithelial apicobasal polarity have been identified. However, the mechanism by… Expand Polarized cells contain numerous membrane domains, but it is unclear how the formation of these domains is coordinated to create… Expand Asymmetric localization is a prerequisite for inscuteable (insc) to function in coordinating and mediating asymmetric cell… Expand The establishment and maintenance of polarity is of fundamental importance for the function of epithelial and neuronal cells. In… Expand BACKGROUND
In the fruit fly Drosophila, the Inscuteable protein localises to the apical cell cortex in neuroblasts and directs… Expand Asymmetric cell divisions can be generated by the segregation of determinants into one of the two daughter cells. In Drosophila… Expand Asymmetric cell division generates daughter cells with different developmental fates from progenitor cells that contain localized… Expand Cellularization of the Drosophila embryo results in the formation of a cell monolayer with many characteristics of a polarized… Expand