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PAR-1-activating peptide

Known as: PAR-1-AP, TFLLR-NH2, threonyl-phenylalanyl-leucyl-leucyl-argininamide 
 
National Institutes of Health

Related topics

Related topics

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Broader (1)

Oligopeptides

Papers overview

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2012
2012
Combined argatroban and anti‐oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid haemorrhage
BACKGROUND AND PURPOSE Increased vascular contractility plays a fundamental role in cerebral vasospasm in subarachnoid… Expand
Highly Cited
2011
Highly Cited
2011
Distinct platelet packaging, release, and surface expression of proangiogenic and antiangiogenic factors on different platelet stimuli.
The present study characterized platelet secretion and surface expression of proangiogenic stromal cell-derived factor-1α (SDF-1… Expand
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Highly Cited
2011
Highly Cited
2011
Release of sphingosine‐1‐phosphate from human platelets is dependent on thromboxane formation
Summary.  Background: Platelets release the immune‐modulating lipid sphingosine‐1‐phosphate (S1P). However, the mechanisms of… Expand
2008
2008
Platelet PAR1 receptor density--correlation to platelet activation response and changes in exposure after platelet activation.
INTRODUCTION A polymorphism (-14 A/T) affecting PAR1 expression on the platelet surface has recently been identified. A two-fold… Expand
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2007
2007
Mechanisms for prostaglandin E2 formation caused by proteinase-activated receptor-1 activation in rat gastric mucosal epithelial cells.
Proteinase-activated receptor-1 (PAR1), a thrombin receptor, plays a protective role in gastric mucosa via prostanoid formation… Expand
2007
2007
Protease-Activated Receptors Differentially Regulate Human Platelet Activation through a Phosphatidic Acid-Dependent Pathway
Pathological conditions such as coronary artery disease are clinically controlled via therapeutic regulation of platelet activity… Expand
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Highly Cited
2004
Highly Cited
2004
Differential Ca2+ signaling by thrombin and protease-activated receptor-1-activating peptide in human brain microvascular endothelial cells.
Thrombin and related protease-activated receptors 1, 2, 3, and 4 (PAR1-4) play a multifunctional role in many types of cells… Expand
Highly Cited
2002
Highly Cited
2002
Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways.
Protease-activated receptors (PARs), newly identified members of G protein-coupled receptors, are widely distributed in the brain… Expand
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Highly Cited
2002
Highly Cited
2002
Proteinase‐activated receptor‐1 agonists attenuate nociception in response to noxious stimuli
Proteinase‐activated receptor‐1 (PAR‐1) is activated by thrombin and can be selectively activated by synthetic peptides (PAR‐1… Expand
2001
2001
Mechanism of trypsin‐induced contraction in the rat myometrium: the possible involvement of a novel member of protease‐activated receptor
The mechanism of trypsin‐induced contraction in the rat myometrium was investigated using front‐surface fluorimetry on fura‐PE3… Expand
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