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PAR-1-activating peptide

Known as: PAR-1-AP, TFLLR-NH2, threonyl-phenylalanyl-leucyl-leucyl-argininamide 
 
National Institutes of Health

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Related topics

1 relation

Broader (1)

Oligopeptides

Papers overview

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2012
2012
Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid haemorrhage.
BACKGROUND AND PURPOSE Increased vascular contractility plays a fundamental role in cerebral vasospasm in subarachnoid… Expand
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Highly Cited
2011
Highly Cited
2011
Distinct platelet packaging, release, and surface expression of proangiogenic and antiangiogenic factors on different platelet stimuli.
The present study characterized platelet secretion and surface expression of proangiogenic stromal cell-derived factor-1α (SDF-1… Expand
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Highly Cited
2011
Highly Cited
2011
Release of sphingosine-1-phosphate from human platelets is dependent on thromboxane formation.
BACKGROUND Platelets release the immune-modulating lipid sphingosine-1-phosphate (S1P). However, the mechanisms of platelet S1P… Expand
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2008
2008
Platelet PAR1 receptor density--correlation to platelet activation response and changes in exposure after platelet activation.
INTRODUCTION A polymorphism (-14 A/T) affecting PAR1 expression on the platelet surface has recently been identified. A two-fold… Expand
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2007
2007
Protease-Activated Receptors Differentially Regulate Human Platelet Activation through a Phosphatidic Acid-Dependent Pathway
Pathological conditions such as coronary artery disease are clinically controlled via therapeutic regulation of platelet activity… Expand
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2004
2004
Differential Ca2+ signaling by thrombin and protease-activated receptor-1-activating peptide in human brain microvascular endothelial cells.
Thrombin and related protease-activated receptors 1, 2, 3, and 4 (PAR1-4) play a multifunctional role in many types of cells… Expand
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2003
2003
Thrombin-induced platelet activation and its inhibition by anticoagulants with different modes of action.
Thrombin-induced platelet activation involves cleavage of protease-activated receptors (PARs) 1 and 4, and interaction, via… Expand
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Highly Cited
2002
Highly Cited
2002
Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways.
Protease-activated receptors (PARs), newly identified members of G protein-coupled receptors, are widely distributed in the brain… Expand
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2002
2002
Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli.
Proteinase-activated receptor-1 (PAR-1) is activated by thrombin and can be selectively activated by synthetic peptides (PAR-1… Expand
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2001
2001
Thrombin and PAR-1 activating peptide increase iNOS expression in cytokine-stimulated C6 glioma cells.
Thrombin (THR) plays a key role in the brain under physiological and pathological conditions. Several of the biological… Expand
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