Oxypurinol

Known as: DHPP, 1H-Pyrazolo[3,4-d]pyrimidine-4,6-diol, Oxipurinolum 
A xanthine oxidase inhibitor.
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
OBJECTIVES This study evaluated whether a xanthine oxidase (XO) inhibitor, oxypurinol, produces clinical benefits in patients… (More)
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Review
2007
Review
2007
Allopurinol is the drug most widely used to lower the blood concentrations of urate and, therefore, to decrease the number of… (More)
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Highly Cited
2007
Highly Cited
2007
Ischemia is a major cause of brain damage, and patient management is complicated by the paradoxical injury that results from… (More)
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Highly Cited
2003
Highly Cited
2003
Oscillatory shear stress occurs at sites of the circulation that are vulnerable to atherosclerosis. Because oxidative stress… (More)
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Highly Cited
2000
Highly Cited
2000
Xanthine oxidase (XO) was shown to catalyze the reduction of nitrite to nitric oxide (NO), under anaerobic conditions, in the… (More)
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Highly Cited
1998
Highly Cited
1998
Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN… (More)
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Highly Cited
1997
Highly Cited
1997
Hypercholesterolemic and hypertensive patients have impaired endothelium-dependent vasorelaxation because of decreased nitric… (More)
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Highly Cited
1993
Highly Cited
1993
Indirect evidence suggests accelerated degradation of endothelium-derived nitric oxide (ENDO) by superoxide anion (O2-) in… (More)
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Highly Cited
1991
Highly Cited
1991
Although active oxygen species play important roles in the pathogenesis of various diseases, the molecular mechanism for oxygen… (More)
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Highly Cited
1987
Highly Cited
1987
Allopurinol is a scavenger of the highly reactive hydroxyl radical (k2 approx. 10(9) M-1 X s-1). One product of attack of… (More)
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