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Cancer cells have metabolic dependencies that distinguish them from their normal counterparts. Among these dependencies is an… Expand ABSTRACT Malic acid is a potential biomass-derivable “building block” for chemical synthesis. Since wild-type Saccharomyces… Expand Tumor cell proliferation requires rapid synthesis of macromolecules including lipids, proteins, and nucleotides. Many tumor cells… Expand Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix-PAS domain transcription factor that is expressed in all metazoan… Expand In many organisms, metabolite interconversion at the phosphoenolpyruvate (PEP)-pyruvate-oxaloacetate node involves a structurally… Expand Metabolic profiling analyses were performed to determine metabolite temporal dynamics associated with the induction of acquired… Expand Addition of insulin or a physiological ratio of ketone bodies to buffer with 10 mM glucose increased efficiency (hydraulic work… Expand The effects of starvation, glucose refeeding, dibutyryl cAMP, and dexamethasone on expression of the gene for phosphoenolpyruvate… Expand Abstract— Sustained epileptic seizures were induced in paralysed, artificially ventilated and anaesthetized (70% N2O) rats by… Expand 1. The concentrations of the oxidized and reduced substrates of the lactate-, beta-hydroxybutyrate- and glutamate-dehydrogenase… Expand