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Ornithine Carbamoyltransferase, Mitochondrial, human

Known as: EC 2.1.3.3, Ornithine Transcarbamylase, OTCase 
Ornithine carbamoyltransferase, mitochondrial (354 aa, ~40 kDa) is encoded by the human OTC gene. This protein plays a role in the metabolism of… Expand
National Institutes of Health

Related topics

Related topics

5 relations
Enzyme GeneHomo sapiensOTC geneprotein metabolism

Broader (1)

ORNITHINE CARBAMOYLTRANSFERASE

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
The arginine regulon of Escherichia coli: whole-system transcriptome analysis discovers new genes and provides an integrated view of arginine regulation.
Analysis of the response to arginine of the Escherichia coli K-12 transcriptome by microarray hybridization and real-time… Expand
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Highly Cited
2004
Highly Cited
2004
The biochemical and molecular spectrum of ornithine transcarbamylase deficiency
Ornithine transcarbamylase (OTCase) deficiency, the most commoninherited urea cycle disorder, is transmitted as an X-linked trait… Expand
Review
2004
Review
2004
Biosynthesis of Arginine and Polyamines.
Early investigations on arginine biosynthesis brought to light basic features of metabolic regulation. The most significant… Expand
Highly Cited
1998
Highly Cited
1998
The crystal structure of Pyrococcus furiosus ornithine carbamoyltransferase reveals a key role for oligomerization in enzyme stability at extremely high temperatures.
The Pyrococcus furiosus (PF) ornithine carbamoyltransferase (OTCase; EC 2.1.3.3) is an extremely heat-stable enzyme that… Expand
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1997
1997
Substrate-induced conformational change in a trimeric ornithine transcarbamoylase.
The crystal structure of Escherichia coli ornithine transcarbamoylase (OTCase, EC 2.1.3.3) complexed with the bisubstrate analog… Expand
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Highly Cited
1996
Highly Cited
1996
The urea cycle of Helicobacter pylori.
The presence and activities of the enzymes of the urea cycle in the bacterium Helicobacter pylori were investigated employing one… Expand
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Highly Cited
1995
Highly Cited
1995
Induction of ornithine-urea cycle enzymes and nitrogen metabolism and excretion in rainbow trout (Oncorhynchus mykiss) during early life stages
The ornithine­urea cycle (OUC) is present in elasmobranch fish and many terrestrial vertebrates. Recently, a functional OUC has… Expand
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Review
1986
Review
1986
Biosynthesis and metabolism of arginine in bacteria.
INTRODUCTION ...................................................... 315 BIOSYNTHESIS OF ARGININE… Expand
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Highly Cited
1984
Highly Cited
1984
Evolutionary divergence of genes for ornithine and aspartate carbamoyl-transferases--complete sequence and mode of regulation of the Escherichia coli argF gene; comparison of argF with argI and pyrB.
The complete nucleotide sequence of argF is presented, together with that of an operator-constitutive mutant. ArgF is compared… Expand
Highly Cited
1983
Highly Cited
1983
Cloning and characterization of the ornithine carbamoyltransferase gene from Aspergillus nidulans.
An Aspergillus nidulans DNA fragment composed of two adjacent SalI subfragments (1.8 and 0.85 kb) that carries an argB gene… Expand
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