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Oligophrenin-1

Known as: ARHGAP41, Oligophrenin 1, Rho GTPase-Activating Protein 41 
Oligophrenin-1 (802 aa, ~92 kDa) is encoded by the human OPHN1 gene. This protein plays a role in GTP hydrolysis.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Oligophrenin-1 (OPHN1) encodes a Rho-GTPase-activating protein (Rho-GAP) whose loss of function has been associated with X-linked… Expand
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2008
2008
Mutations in regulators and effectors of the Rho GTPases underlie various forms of mental retardation (MR). Among them… Expand
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Highly Cited
2007
Highly Cited
2007
Loss of oligophrenin1 (OPHN1) function in human causes X-linked mental retardation associated with cerebellar hypoplasia and, in… Expand
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Highly Cited
2005
Highly Cited
2005
Background: Mutations of oligophrenin 1, one of the first genes identified in nonspecific X-linked mental retardation (MRX), have… Expand
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Highly Cited
2004
Highly Cited
2004
Of 11 genes involved in nonspecific X-linked mental retardation (MRX), three encode regulators or effectors of the Rho GTPases… Expand
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Highly Cited
2004
Highly Cited
2004
Oligophrenin‐1 (OPHN‐1) gene disruption is known as responsible for so called “non‐specific” X‐linked mental retardation (MR… Expand
Highly Cited
2003
Highly Cited
2003
A number of apparently non-syndromic X linked mental retardation syndromes are associated with subtle but characteristic… Expand
Review
2002
Review
2002
  • G. Ramakers
  • Trends in Neurosciences
  • 2002
  • Corpus ID: 13941716
For several decades, it has been known that mental retardation (MR) is associated with abnormalities in dendrites and dendritic… Expand
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Highly Cited
1998
Highly Cited
1998
Primary or nonspecific X-linked mental retardation (MRX) is a heterogeneous condition in which affected patients do not have any… Expand
1998
1998
Mental retardation is a common phenotype that is caused by defects in a large number of genes--the updated McKusick catalogue of… Expand