Oligonucleotide Synthesis

Known as: Synthesis, Oligonucleotide 
The process of producing oligonucleotides by the union of simpler chemical compounds.
National Institutes of Health

Papers overview

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2003
2003
Novel photoacid generators for photodirected oligonucleotide synthesis.
Photodirected oligonucleotide synthesis uses either direct or indirect light-dependent 5'-deprotection. Both have been reported… (More)
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2003
2003
Novel photocleavable universal support for oligonucleotide synthesis.
A novel photocleavable universal support for the automated solid phase synthesis of oligonucleotides is described. The linker… (More)
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2003
2003
A conformationally preorganized universal solid support for efficient oligonucleotide synthesis.
A novel, conformationally preorganized nonnucleosidic universal solid support for oligonucleotide synthesis was developed. The… (More)
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1999
1999
Trityl mass-tags for encoding in combinatorial oligonucleotide synthesis.
Combinatorial libraries of oligonucleotides on beads were synthesised by a split-and-mix strategy using 5'-DMTr- or 5'-Fmoc… (More)
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1998
1998
Efficient activation of nucleoside phosphoramidites with 4,5-dicyanoimidazole during oligonucleotide synthesis.
A new activator for the coupling of phosphoramidites to the 5'-hydroxyl group during oligonucleotide synthesis is introduced. The… (More)
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1997
1997
Oligonucleotide dendrimers: synthesis and use as polylabelled DNA probes.
Oligonucleotide dendrimers were synthesized using a novel phosphoramidite synthon, tris-2,2,2-[3-(4,4'-dimethoxytrityloxy… (More)
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1997
1997
Hydroquinone-O,O'-diacetic acid ('Q-linker') as a replacement for succinyl and oxalyl linker arms in solid phase oligonucleotide synthesis.
When hydroquinone-O,Ooffiacetic acid is used as a linker arm in solid phase oligonucleotide synthesis, the time for NH4OH… (More)
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1996
1996
Acid binding and detritylation during oligonucleotide synthesis.
Under the conditions normally used for detritylation in oligonucleotide synthesis, the haloacetic acid binds strongly to the… (More)
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1996
1996
Kinetic studies on depurination and detritylation of CPG-bound intermediates during oligonucleotide synthesis.
Fully protected CPG-immobilized monomer, dimer and trimer oligonucleotides were used to study depurination during the chemical… (More)
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1990
1990
Computer simulation in template-directed oligonucleotide synthesis
A computer simulation (KINSIM) modeling up to 33 competing reactions was used in order to investigate the product distribution in… (More)
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