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Oligonucleotide Synthesis

Known as: Synthesis, Oligonucleotide 
The process of producing oligonucleotides by the union of simpler chemical compounds.
National Institutes of Health

Papers overview

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2013
2013
Aminosilane functionalizations of mesoporous oxidized silicon for oligonucleotide synthesis and detection
Direct solid phase synthesis of peptides and oligonucleotides (ONs) requires high chemical stability of the support material. In… Expand
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Highly Cited
2005
Highly Cited
2005
In situ oligonucleotide synthesis on poly(dimethylsiloxane): a flexible substrate for microarray fabrication
In this paper, we demonstrate in situ synthesis of oligonucleotide probes on poly(dimethylsiloxane) (PDMS) microchannels through… Expand
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2003
2003
Novel photoacid generators for photodirected oligonucleotide synthesis.
Photodirected oligonucleotide synthesis uses either direct or indirect light-dependent 5'-deprotection. Both have been reported… Expand
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Highly Cited
1998
Highly Cited
1998
Efficient activation of nucleoside phosphoramidites with 4,5-dicyanoimidazole during oligonucleotide synthesis.
A new activator for the coupling of phosphoramidites to the 5'-hydroxyl group during oligonucleotide synthesis is introduced. The… Expand
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Highly Cited
1997
Highly Cited
1997
Oligonucleotide dendrimers: synthesis and use as polylabelled DNA probes.
Oligonucleotide dendrimers were synthesized using a novel phosphoramidite synthon, tris-2,2,2-[3-(4,4'-dimethoxytrityloxy… Expand
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1996
1996
Kinetic studies on depurination and detritylation of CPG-bound intermediates during oligonucleotide synthesis.
  • M. Septak
  • Nucleic acids research
  • 1996
    • Corpus ID: 15815955
Fully protected CPG-immobilized monomer, dimer and trimer oligonucleotides were used to study depurination during the chemical… Expand
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Highly Cited
1992
Highly Cited
1992
Oligonucleotide hybridizations on glass supports: a novel linker for oligonucleotide synthesis and hybridization properties of oligonucleotides synthesised in situ.
A novel linker for the synthesis of oligonucleotides on a glass support is described. Oligonucleotides synthesised on the support… Expand
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Highly Cited
1987
Highly Cited
1987
Mechanistic studies on the phosphoramidite coupling reaction in oligonucleotide synthesis. I. Evidence for nucleophilic catalysis by tetrazole and rate variations with the phosphorus substituents.
Tetrazole catalyzed reactions of a series of phosphoramidites, 5'-O-DMTdT-3'-O-P(OR1)NR2(2) (1a-h), with 3'-O-SiButPh2-6-N… Expand
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1986
1986
Application of new catalytic phosphate protecting groups for the highly efficient phosphotriester oligonucleotide synthesis.
An effective procedure for the synthesis of oligonucleotides by the phosphotriester method has been developed. The procedure is… Expand
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Highly Cited
1985
Highly Cited
1985
New, ionic side-products in oligonucleotide synthesis: formation and reactivity of fluorescent N-/purin-6-yl/pyridinium salts.
Fluorescent N-/purin-6-yl/pyridinium salts are formed in pyridine assisted phosphorylations and arenesulphonations of the… Expand
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