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Oligodeoxyribonucleotides, Antisense

Known as: Antisense Oligodeoxyribonucleotide, Anti-Sense Oligodeoxyribonucleotides, Oligodeoxyribonucleotide, Antisense 
Short fragments of DNA that are used to alter the function of target RNAs or DNAs to which they hybridize.
National Institutes of Health

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GEM91MG 98OL(1)p53mipomersen
In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

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Highly Cited
2009
Highly Cited
2009
Transferrin receptor-targeted lipid nanoparticles for delivery of an antisense oligodeoxyribonucleotide against Bcl-2.
Antisense oligonucleotide G3139-mediated down-regulation of Bcl-2 is a potential strategy for overcoming chemoresistance in… 
Highly Cited
2009
Highly Cited
2009
A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference
Anti-miRNA antisense inhibitors (AMOs) have demonstrated their utility in miRNA research and potential in miRNA therapy. Here we… 
Highly Cited
2003
Highly Cited
2003
Biophysical and biological properties of quadruplex oligodeoxyribonucleotides.
Single-stranded guanosine-rich oligodeoxyribonucleotides (GROs) have a propensity to form quadruplex structures that are… 
Highly Cited
2001
Highly Cited
2001
Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms.
The mouse double minute 2 (MDM2) oncogene has been suggested as a target for cancer therapy. It is amplified or overexpressed in… 
Highly Cited
1999
Highly Cited
1999
Exercise Provides Direct Biphasic Cardioprotection via Manganese Superoxide Dismutase Activation
Epidemiologic investigations have shown that exercise reduces morbidity and mortality from coronary artery disease. In this study… 
Highly Cited
1995
Highly Cited
1995
Possible Participation of Autocrine and Paracrine Vascular Endothelial Growth Factors in Hypoxia-induced Proliferation of Endothelial Cells and Pericytes (*)
Hypoxia is the principal factor that causes angiogenesis. These experiments were conducted to explore how it induces the… 
Highly Cited
1991
Highly Cited
1991
Erythropoietin induces Raf-1 activation and Raf-1 is required for erythropoietin-mediated proliferation.
Highly Cited
1989
Highly Cited
1989
Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides.
We have studied the translation of rabbit globin mRNA in cell free systems (reticulocyte lysate and wheat germ extract) and in… 
Highly Cited
1987
Highly Cited
1987
A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1
Initiation of T-lymphocyte proliferation by mitogen or antigen involves a cascade of gene activation events. Thus, by the time… 
Highly Cited
1987
Highly Cited
1987
Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site.
Antisense oligonucleotides represent an interesting tool for selective inhibition of gene expression, but their efficient… 
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