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Ofloxacin

Known as: 8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid, (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7- -oxo-7H-pyrido(1,2,3-de)- -1,4-benzoxazine-6-carboxylic acid, Ofloxacinum 
A fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes… 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
SETTING Current treatment for pulmonary tuberculosis (TB) might be shortened by the incorporation of fluoroquinolones (FQs… 
Highly Cited
2006
Highly Cited
2006
Oral sustained release gastroretentive dosage forms offer many advantages for drugs having absorption from upper gastrointestinal… 
Highly Cited
2004
Highly Cited
2004
In this study, water extract of nettle (Urtica dioica L.) (WEN) was studied for antioxidant, antimicrobial, antiulcer and… 
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Highly Cited
2003
Highly Cited
2003
In this study, antioxidant and antimicrobial activities of water and ethanol extracts of anise (Pimpinella anisum L.) seed (PAS… 
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Highly Cited
2003
Highly Cited
2003
The presence of pharmaceutical compounds in surface waters is an emerging environmental issue. Sewage treatment plants (STPs) are… 
Highly Cited
2001
Highly Cited
2001
The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal… 
Highly Cited
2001
Highly Cited
2001
BACKGROUND The role of antibiotics in treatment of patients with moderate exacerbations of chronic obstructive pulmonary disease… 
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Q fever endocarditis, caused by Coxiella burnetii, is fatal in 25% to 60% of patients. Currently, treatment with a… 
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Review
1988
Review
1988
Ciprofloxacin is one of a new generation of fluorinated quinolones structurally related to nalidixic acid. The primary mechanism… 
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