Ofloxacin

Known as: 8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid, (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7- -oxo-7H-pyrido(1,2,3-de)- -1,4-benzoxazine-6-carboxylic acid, Ofloxacinum 
A fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
RATIONALE Central dogma suggests that rifampicin resistance in Mycobacterium tuberculosis develops solely through rpoB gene… (More)
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Highly Cited
2008
Highly Cited
2008
SETTING Current treatment for pulmonary tuberculosis (TB) might be shortened by the incorporation of fluoroquinolones (FQs… (More)
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Highly Cited
2007
Highly Cited
2007
Isolates of Salmonella enterica serovar Typhi that are multidrug resistant (MDR, resistant to chloramphenicol, ampicillin, and… (More)
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Highly Cited
2004
Highly Cited
2004
Bacterial populations produce persister cells that neither grow nor die in the presence of microbicidal antibiotics. Persisters… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE We compared the in vitro susceptibility patterns and the minimum inhibitory concentrations (MICs) of gatifloxacin (GAT… (More)
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Highly Cited
2001
Highly Cited
2001
Biofilms are considered to be highly resistant to antimicrobial agents. Strictly speaking, this is not the case-biofilms do not… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND The role of antibiotics in treatment of patients with moderate exacerbations of chronic obstructive pulmonary disease… (More)
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE To analyze outcomes of patients with multidrug-resistant tuberculosis (MDR-TB) treated with ofloxacin/levofloxacin… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Q fever endocarditis, caused by Coxiella burnetii, is fatal in 25% to 60% of patients. Currently, treatment with a… (More)
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Highly Cited
1997
Highly Cited
1997
Oral therapy of staphylococcal infection of orthopaedic implants with 900 mg/day rifampicin combined with either 1.5 g/day… (More)
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