OPTN protein, human

Known as: E3-14.7K-Interacting Protein, tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains, human, Huntingtin-Interacting Protein 7 
Optineurin (577 aa, ~66 kDa) is encoded by the human OPTN gene. This protein plays a role in the maintenance of both neurons and the Golgi apparatus.
National Institutes of Health

Papers overview

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Review
2014
Review
2014
The ubiquitin-proteasome system and autophagy were long viewed as independent, parallel degradation systems with no point of… (More)
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Highly Cited
2013
Highly Cited
2013
Aggregation of misfolded proteins and the associated loss of neurons are considered a hallmark of numerous neurodegenerative… (More)
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Highly Cited
2009
Highly Cited
2009
TNF is a key inflammatory cytokine. Using a modified tandem affinity purification approach, we identified HOIL-1 and HOIP as… (More)
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Highly Cited
2009
Highly Cited
2009
A hallmark of polyglutamine diseases, including Huntington disease (HD), is the formation of beta-sheet-rich aggregates, called… (More)
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Highly Cited
2006
Highly Cited
2006
Expansion of a polyglutamine tract in the huntingtin protein causes neuronal degeneration and death in Huntington's disease… (More)
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Highly Cited
2005
Highly Cited
2005
Huntington disease is caused by a polyglutamine expansion in the huntingtin protein (Htt) and is associated with excitotoxic… (More)
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Highly Cited
2004
Highly Cited
2004
The NF-kappaB family of transcription factors is activated in response to many stimuli, including pro-inflammatory cytokines… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Crohn's disease is an autoimmune inflammatory disorder of the gastrointestinal tract and is characterized clinically… (More)
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Highly Cited
2002
Highly Cited
2002
Primary open-angle glaucoma (POAG) affects 33 million individuals worldwide and is a leading cause of blindness. In a study of 54… (More)
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Highly Cited
1998
Highly Cited
1998
Early region 3 (E3) of group C human adenoviruses (Ad) encodes several inhibitors of tumor necrosis factor alpha (TNF-alpha… (More)
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