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ONO 5046

Known as: ONO-5046 
 
National Institutes of Health

Papers overview

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2005
2005
The protective effects of a neutrophil elastase inhibitor (ONO-5046) on cerulein-induced pancreatitis followed by a septic… Expand
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Highly Cited
2001
Highly Cited
2001
In view of a cytoprotective effect of elastase inhibitor on chemokine‐mediated tissue injury, we examined the neuroprotective… Expand
Highly Cited
2000
Highly Cited
2000
It has been reported that activated neutrophils are involved in the development of cerebral damage induced by ischemia. Activated… Expand
2000
2000
Reactive oxygen and neutrophil metabolites have been implicated in the development of hyperoxic lung injury. We determined the… Expand
Highly Cited
1998
Highly Cited
1998
The aim of this study was to examine the effect of ONO-5046, a neutrophil elastase (NE) inhibitor, on a model of acute lung… Expand
1998
1998
ONO-5046 is a potent, specific and intravenously active inhibitor of neutrophil elastase. To examine the role of elastase in… Expand
Highly Cited
1997
Highly Cited
1997
Endotoxin causes acute lung injury resembling acute respiratory distress syndrome.Elastase, as well as reactive oxygen species… Expand
1997
1997
Background Acid instillation leads to direct lung and to secondary systemic organ injury, probably via activated macrophages and… Expand
Highly Cited
1997
Highly Cited
1997
Neutrophils play an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). To elucidate the possible… Expand
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Highly Cited
1996
Highly Cited
1996
Because excessive neutrophil elastase (NE) activity is involved in the pathogenesis of acute lung injury, we speculated that… Expand