ONO 5046

Known as: ONO-5046 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2015
051019912015

Papers overview

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2009
2009
Prevention of paraplegia remains an important issue in repair of descending thoracic and thoracoabdominal aneurysms. Therefore… (More)
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2004
2004
Evidence has linked neutrophil elastase to acute respiratory distress syndrome (ARDS), suggesting that inhibiting the activity of… (More)
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2001
2001
In view of a cytoprotective effect of elastase inhibitor on chemokine-mediated tissue injury, we examined the neuroprotective… (More)
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2001
2001
The underlying mechanisms of lung endothelial injury after intestinal ischemia-reperfusion (I/R) injury are not fully known. Here… (More)
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1998
1998
ONO-5046 is a potent, specific and intravenously active inhibitor of neutrophil elastase. To examine the role of elastase in… (More)
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1997
1997
Endotoxin causes acute lung injury resembling acute respiratory distress syndrome. Elastase, as well as reactive oxygen species… (More)
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1997
1997
BACKGROUND Acid instillation leads to direct lung and to secondary systemic organ injury, probably via activated macrophages and… (More)
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1996
1996
Because excessive neutrophil elastase (NE) activity is involved in the pathogenesis of acute lung injury, we speculated that… (More)
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1994
1994
The purpose of the present study was to assess the role of polymorphonuclear leukocyte (neutrophil) elastase in endotoxin-induced… (More)
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Highly Cited
1991
Highly Cited
1991
ONO-5046, N-[2-[4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino] aminoacetic acid, competitively inhibited human neutrophil… (More)
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