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ONO 5046

Known as: ONO-5046 
National Institutes of Health

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Papers overview

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Review
2012
Review
2012
Direct interaction of ONO-5046 with human neutrophil elastase through ¹H NMR and molecular docking.
Highly Cited
2000
Highly Cited
2000
Neutrophil elastase inhibition reduces cerebral ischemic damage in the middle cerebral artery occlusion
2000
2000
Effects of lecithinized superoxide dismutase and a neutrophil elastase inhibitor (ONO-5046) on hyperoxic lung injury in rat.
1999
1999
Neutrophil elastase inhibitor (ONO-5046) attenuates reperfusion-induced hepatic microcirculatory derangement, energy depletion and lipid peroxidation in rats.
UNLABELLED Microcirculatory derangement, energy depletion, and lipid peroxidation are associated with the development of ischemia… 
1999
1999
Role of neutrophils in xanthine/xanthine oxidase-induced oxidant injury in isolated rabbit lungs.
Reactive oxygen species have been shown to play an important role in the pathogenesis of lung injury. This study was designed to… 
1999
1999
Effect of specific neutrophil elastase inhibitor on ischemia/reperfusion injury in rat liver transplantation.
Activated neutrophils have been implicated as playing an important role in ischemia/reperfusion injury of the liver by releasing… 
1998
1998
ONO-5046, an elastase inhibitor, attenuates liver mitochondrial dysfunction after endotoxin.
OBJECTIVE To investigate the effect of ONO-5046, an elastase inhibitor, on liver mitochondrial dysfunction after endotoxin… 
Highly Cited
1997
Highly Cited
1997
Effects of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice.
Neutrophils play an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). To elucidate the possible… 
1996
1996
Neutrophil elastase inhibitor (ONO-5046) decreases cytokine-induced neutrophil chemoattractant after reperfusion of pancreaticoduodenal transplantation in rats.
The protective effects of a neutrophil elastase inhibitor (ONO-5046) on reperfusion injury following pancreaticoduodenal… 
1995
1995
Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis
The protective effects of a neutrophil elastase inhibitor (ONO-5046) on cerulein-induced pancreatitis followed by a septic… 
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