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ONO 5046

Known as: ONO-5046 
National Institutes of Health

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Highly Cited
2001
Highly Cited
2001
A neutrophil elastase inhibitor (ONO‐5046) reduces neurologic damage after spinal cord injury in rats
In view of a cytoprotective effect of elastase inhibitor on chemokine‐mediated tissue injury, we examined the neuroprotective… 
Highly Cited
2000
Highly Cited
2000
Neutrophil elastase inhibition reduces cerebral ischemic damage in the middle cerebral artery occlusion
Highly Cited
1998
Highly Cited
1998
Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs.
The aim of this study was to examine the effect of ONO-5046, a neutrophil elastase (NE) inhibitor, on a model of acute lung… 
1998
1998
Effects of a novel elastase inhibitor, ONO-5046, on nephrotoxic serum nephritis in rats.
ONO-5046 is a potent, specific and intravenously active inhibitor of neutrophil elastase. To examine the role of elastase in… 
Highly Cited
1997
Highly Cited
1997
ONO-5046, an Elastase Inhibitor, Attenuates Endotoxin-Induced Acute Lung Injury in Rabbits
Endotoxin causes acute lung injury resembling acute respiratory distress syndrome.Elastase, as well as reactive oxygen species… 
1997
1997
Neutrophil Elastase Inhibitor, ONO-5046, Modulates Acid-induced Lung and Systemic Injury in Rabbits
Background Acid instillation leads to direct lung and to secondary systemic organ injury, probably via activated macrophages and… 
Highly Cited
1997
Highly Cited
1997
Effects of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice.
Neutrophils play an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). To elucidate the possible… 
Highly Cited
1996
Highly Cited
1996
Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury.
Because excessive neutrophil elastase (NE) activity is involved in the pathogenesis of acute lung injury, we speculated that… 
1996
1996
Neutrophil elastase inhibitor (ONO-5046) decreases cytokine-induced neutrophil chemoattractant after reperfusion of pancreaticoduodenal transplantation in rats.
The protective effects of a neutrophil elastase inhibitor (ONO-5046) on reperfusion injury following pancreaticoduodenal… 
1995
1995
Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis
The protective effects of a neutrophil elastase inhibitor (ONO-5046) on cerulein-induced pancreatitis followed by a septic… 
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