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ONO 5046

Known as: ONO-5046 
 
National Institutes of Health

Papers overview

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2005
2005
The protective effects of a neutrophil elastase inhibitor (ONO-5046) on cerulein-induced pancreatitis followed by a septic… Expand
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2001
2001
In view of a cytoprotective effect of elastase inhibitor on chemokine-mediated tissue injury, we examined the neuroprotective… Expand
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2000
2000
Reactive oxygen and neutrophil metabolites have been implicated in the development of hyperoxic lung injury. We determined the… Expand
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2000
2000
It has been reported that activated neutrophils are involved in the development of cerebral damage induced by ischemia. Activated… Expand
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1998
1998
The aim of this study was to examine the effect of ONO-5046, a neutrophil elastase (NE) inhibitor, on a model of acute lung… Expand
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1998
1998
ONO-5046 is a potent, specific and intravenously active inhibitor of neutrophil elastase. To examine the role of elastase in… Expand
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1997
1997
Endotoxin causes acute lung injury resembling acute respiratory distress syndrome. Elastase, as well as reactive oxygen species… Expand
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1997
1997
BACKGROUND Acid instillation leads to direct lung and to secondary systemic organ injury, probably via activated macrophages and… Expand
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1997
1997
Neutrophils play an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). To elucidate the possible… Expand
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Highly Cited
1996
Highly Cited
1996
Because excessive neutrophil elastase (NE) activity is involved in the pathogenesis of acute lung injury, we speculated that… Expand
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