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ONO 5046
Known as:
ONO-5046
National Institutes of Health
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Highly Cited
2001
Highly Cited
2001
A neutrophil elastase inhibitor (ONO‐5046) reduces neurologic damage after spinal cord injury in rats
T. Tonai
,
K. Shiba
,
+6 authors
T. Nishisho
Journal of Neurochemistry
2001
Corpus ID: 13522078
In view of a cytoprotective effect of elastase inhibitor on chemokine‐mediated tissue injury, we examined the neuroprotective…
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Highly Cited
2000
Highly Cited
2000
Neutrophil elastase inhibition reduces cerebral ischemic damage in the middle cerebral artery occlusion
A. Shimakura
,
Y. Kamanaka
,
Y. Ikeda
,
K. Kondo
,
Yasuhiro Suzuki
,
K. Umemura
Brain Research
2000
Corpus ID: 3112958
Highly Cited
1998
Highly Cited
1998
Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs.
Y. Miyazaki
,
T. Inoue
,
M. Kyi
,
M. Sawada
,
S. Miyake
,
Y. Yoshizawa
American Journal of Respiratory and Critical Care…
1998
Corpus ID: 44267681
The aim of this study was to examine the effect of ONO-5046, a neutrophil elastase (NE) inhibitor, on a model of acute lung…
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1998
1998
Effects of a novel elastase inhibitor, ONO-5046, on nephrotoxic serum nephritis in rats.
S. Suzuki
,
F. Gejyo
,
+4 authors
M. Arakawa
Kidney International
1998
Corpus ID: 24642187
ONO-5046 is a potent, specific and intravenously active inhibitor of neutrophil elastase. To examine the role of elastase in…
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Highly Cited
1997
Highly Cited
1997
ONO-5046, an Elastase Inhibitor, Attenuates Endotoxin-Induced Acute Lung Injury in Rabbits
K. Nishina
,
K. Mikawa
,
Y. Takao
,
N. Maekawa
,
M. Shiga
,
H. Obara
Anesthesia and Analgesia
1997
Corpus ID: 18261141
Endotoxin causes acute lung injury resembling acute respiratory distress syndrome.Elastase, as well as reactive oxygen species…
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1997
1997
Neutrophil Elastase Inhibitor, ONO-5046, Modulates Acid-induced Lung and Systemic Injury in Rabbits
K. Kaneko
,
I. Kudoh
,
+4 authors
F. Okumura
Anesthesiology
1997
Corpus ID: 26381393
Background Acid instillation leads to direct lung and to secondary systemic organ injury, probably via activated macrophages and…
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Highly Cited
1997
Highly Cited
1997
Effects of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice.
Y. Taooka
,
A. Maeda
,
K. Hiyama
,
S. Ishioka
,
M. Yamakido
American Journal of Respiratory and Critical Care…
1997
Corpus ID: 17278748
Neutrophils play an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). To elucidate the possible…
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Highly Cited
1996
Highly Cited
1996
Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury.
F. Sakamaki
,
A. Ishizaka
,
+10 authors
M. Kanazawa
American Journal of Respiratory and Critical Care…
1996
Corpus ID: 43692825
Because excessive neutrophil elastase (NE) activity is involved in the pathogenesis of acute lung injury, we speculated that…
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1996
1996
Neutrophil elastase inhibitor (ONO-5046) decreases cytokine-induced neutrophil chemoattractant after reperfusion of pancreaticoduodenal transplantation in rats.
F. S. Wang
,
Y. Yamaguchi
,
+6 authors
M. Ogawa
Transplantation
1996
Corpus ID: 10104227
The protective effects of a neutrophil elastase inhibitor (ONO-5046) on reperfusion injury following pancreaticoduodenal…
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1995
1995
Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis
Lei Guo
,
Y. Yamaguchi
,
S. Ikei
,
H. Sugita
,
M. Ogawa
Digestive Diseases and Sciences
1995
Corpus ID: 1234136
The protective effects of a neutrophil elastase inhibitor (ONO-5046) on cerulein-induced pancreatitis followed by a septic…
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