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ONO 5046
Known as:
ONO-5046
National Institutes of Health
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Review
2012
Review
2012
Direct interaction of ONO-5046 with human neutrophil elastase through ¹H NMR and molecular docking.
Li Feng
,
Weiliang Zhu
,
Cheng Huang
,
Yiming Li
International Journal of Biological…
2012
Corpus ID: 25907566
Highly Cited
2000
Highly Cited
2000
Neutrophil elastase inhibition reduces cerebral ischemic damage in the middle cerebral artery occlusion
A. Shimakura
,
Y. Kamanaka
,
Y. Ikeda
,
K. Kondo
,
Yasuhiro Suzuki
,
K. Umemura
Brain Research
2000
Corpus ID: 3112958
2000
2000
Effects of lecithinized superoxide dismutase and a neutrophil elastase inhibitor (ONO-5046) on hyperoxic lung injury in rat.
Hiroshi Yamamoto
,
T. Koizumi
,
T. Kaneki
,
M. Hanaoka
,
Keishi Kubo
European Journal of Pharmacology
2000
Corpus ID: 32981121
1999
1999
Neutrophil elastase inhibitor (ONO-5046) attenuates reperfusion-induced hepatic microcirculatory derangement, energy depletion and lipid peroxidation in rats.
H. M. Chen
,
J. C. Chen
,
+5 authors
C. Chi
Shock
1999
Corpus ID: 20412895
UNLABELLED Microcirculatory derangement, energy depletion, and lipid peroxidation are associated with the development of ischemia…
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1999
1999
Role of neutrophils in xanthine/xanthine oxidase-induced oxidant injury in isolated rabbit lungs.
M. Kishi
,
L. F. Richard
,
R. Webster
,
T. Dahms
Journal of applied physiology
1999
Corpus ID: 7804216
Reactive oxygen species have been shown to play an important role in the pathogenesis of lung injury. This study was designed to…
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1999
1999
Effect of specific neutrophil elastase inhibitor on ischemia/reperfusion injury in rat liver transplantation.
Y. Soejima
,
Katsuhiko Yanaga
,
Takashi Nishizaki
,
T. Yoshizumi
,
H. Uchiyama
,
K. Sugimachi
Journal of Surgical Research
1999
Corpus ID: 21818691
Activated neutrophils have been implicated as playing an important role in ischemia/reperfusion injury of the liver by releasing…
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1998
1998
ONO-5046, an elastase inhibitor, attenuates liver mitochondrial dysfunction after endotoxin.
A. Kudoh
,
E. Kudoh
,
H. Ishihara
,
A. Matsuki
Critical Care Medicine
1998
Corpus ID: 40134642
OBJECTIVE To investigate the effect of ONO-5046, an elastase inhibitor, on liver mitochondrial dysfunction after endotoxin…
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Highly Cited
1997
Highly Cited
1997
Effects of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice.
Y. Taooka
,
A. Maeda
,
K. Hiyama
,
S. Ishioka
,
M. Yamakido
American Journal of Respiratory and Critical Care…
1997
Corpus ID: 17278748
Neutrophils play an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). To elucidate the possible…
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1996
1996
Neutrophil elastase inhibitor (ONO-5046) decreases cytokine-induced neutrophil chemoattractant after reperfusion of pancreaticoduodenal transplantation in rats.
Feng-Shan Wang
,
Y. Yamaguchi
,
+6 authors
M. Ogawa
Transplantation
1996
Corpus ID: 10104227
The protective effects of a neutrophil elastase inhibitor (ONO-5046) on reperfusion injury following pancreaticoduodenal…
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1995
1995
Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis
Lei Guo
,
Y. Yamaguchi
,
S. Ikei
,
H. Sugita
,
M. Ogawa
Digestive Diseases and Sciences
1995
Corpus ID: 1234136
The protective effects of a neutrophil elastase inhibitor (ONO-5046) on cerulein-induced pancreatitis followed by a septic…
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