ONO 5046

The protective effects of a neutrophil elastase inhibitor (ONO-5046) on cerulein-induced pancreatitis followed by a septic… Expand

In view of a cytoprotective effect of elastase inhibitor on chemokine‐mediated tissue injury, we examined the neuroprotective… Expand

It has been reported that activated neutrophils are involved in the development of cerebral damage induced by ischemia. Activated… Expand

Reactive oxygen and neutrophil metabolites have been implicated in the development of hyperoxic lung injury. We determined the… Expand

The aim of this study was to examine the effect of ONO-5046, a neutrophil elastase (NE) inhibitor, on a model of acute lung… Expand

ONO-5046 is a potent, specific and intravenously active inhibitor of neutrophil elastase. To examine the role of elastase in… Expand

Endotoxin causes acute lung injury resembling acute respiratory distress syndrome.Elastase, as well as reactive oxygen species… Expand

Background Acid instillation leads to direct lung and to secondary systemic organ injury, probably via activated macrophages and… Expand

Neutrophils play an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). To elucidate the possible… Expand

Because excessive neutrophil elastase (NE) activity is involved in the pathogenesis of acute lung injury, we speculated that… Expand