ONC201

Known as: Akt/ERK Inhibitor ONC201 
A water soluble, orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) and extracellular signal-regulated… (More)

Topic mentions per year

Topic mentions per year

2014-2018
0246820142018

Papers overview

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2017
2017
Purpose: ONC201 is a small-molecule selective antagonist of the G protein-coupled receptor DRD2 that is the founding member of… (More)
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2016
2016
The clinical challenge posed by p53 abnormalities in hematological malignancies requires therapeutic strategies other than… (More)
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2016
2016
ONC201 (also called TIC10) is a small molecule that inactivates the cell proliferation- and cell survival-promoting kinases Akt… (More)
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2016
2016
We here tested the anti-colorectal cancer (CRC) activity by a first-in-class small molecule TRAIL inducer ONC201. The potential… (More)
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Review
2016
Review
2016
The small molecule ONC201 was identified in a screen for compounds that would induce expression of the gene encoding tumor… (More)
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2015
2015
ONC201/TIC10 is a small molecule initially discovered by its ability to coordinately induce and activate the TRAIL pathway… (More)
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2015
2015
Tumor necrosis factor (TNF) –related apoptosisinducing ligand (TRAIL) is an immuno-surveillance cytokine that is expressed in… (More)
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2015
2015
We previously identified ONC201 (TIC10) as a first-in-class orally active small molecule with robust antitumor activity that is… (More)
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2015
2015
ONC201/TIC10 is a small-molecule inducer of the TRAIL gene under current investigation as a novel anticancer agent. In this study… (More)
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2014
2014
We previously identified TRAIL-inducing compound 10 (TIC10), also known as NSC350625 or ONC201, from a NCI chemical library… (More)
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