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ONC201

Known as: Akt/ERK Inhibitor ONC201 
A water soluble, orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) and extracellular signal-regulated… Expand
National Institutes of Health

Papers overview

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2018
2018
We report a novel mechanism of action of ONC201 as a mitochondria-targeting drug in cancer cells. ONC201 was originally… Expand
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2017
2017
Purpose: ONC201 is a small-molecule selective antagonist of the G protein–coupled receptor DRD2 that is the founding member of… Expand
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2017
2017
ONC201 is an oral, small molecule selective antagonist of the G protein-coupled receptor DRD2 that causes p53-independent… Expand
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Highly Cited
2016
Highly Cited
2016
ONC201 triggers an apoptotic cellular stress response in both solid and blood tumors. Stressing cancer cells to death The… Expand
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Highly Cited
2016
Highly Cited
2016
ONC201 triggers an apoptotic cellular stress response in both solid and blood tumors. Stressing cancer cells to death The… Expand
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Review
2016
Review
2016
ONC201 is the founding member of a novel class of anti-cancer compounds called imipridones that is currently in Phase II clinical… Expand
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Review
2016
Review
2016
Two studies find that the small molecule ONC201 induces cancer cell death through cellular stress–related pathways. The small… Expand
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2015
2015
ONC201/TIC10 is a small-molecule inducer of the TRAIL gene under current investigation as a novel anticancer agent. In this study… Expand
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2015
2015
ONC201/TIC10 is a small molecule initially discovered by its ability to coordinately induce and activate the TRAIL pathway… Expand
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2015
2015
We previously identified ONC201 (TIC10) as a first-in-class orally active small molecule with robust antitumor activity that is… Expand
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