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OMP-54F28

Known as: OMP 54F28 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (4)

G-Protein-Coupled ReceptorsImmunoglobulin Fc FragmentsIpafriceptRecombinant Fusion Proteins

Papers overview

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2018
2018
Wnt signaling dynamics in head and neck squamous cell cancer tumor‐stroma interactions
Wnt pathway activation maintains the cancer stem cell (CSC) phenotype and promotes tumor progression, making it an attractive… 
Highly Cited
2017
Highly Cited
2017
A First-in-Human Phase I Study of the Anticancer Stem Cell Agent Ipafricept (OMP-54F28), a Decoy Receptor for Wnt Ligands, in Patients with Advanced Solid Tumors
Purpose: Wnt signaling is implicated in tumor cell dedifferentiation and cancer stem cell function. Ipafricept (OMP-54F28) is a… 
Review
2017
Review
2017
Molecular genetics and targeted therapy of WNT-related human diseases (Review)
Canonical WNT signaling through Frizzled and LRP5/6 receptors is transduced to the WNT/β-catenin and WNT/stabilization of… 
Review
2015
Review
2015
Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28.
2015
2015
Abstract 4233: Wnt pathway antagonist ipafricept (FZD8-Fc, OMP-54F28) inhibits tumor growth and reduces tumor-initiating cell frequency in ovarian patient-derived xenograft models
Ovarian cancer is the deadliest gynecologic malignancy and the fifth leading cause of death from cancer in women in the U.S. The… 
2014
2014
Abstract 1907: Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor growth and reduces tumor-initiating cell frequency in patient-derived hepatocellular carcinoma and ovarian cancer xenograft…
The Wnt/beta-catenin pathway, which signals through the Frizzled (FZD) receptor family and several co-receptors, has long been… 
2013
2013
Abstract B79: A first-in-human Phase 1 study of anti-cancer stem cell (CSC) agent OMP-54F28 (FZD8-Fc) targeting the WNT pathway in patients with advanced solid tumors.
Introduction: OMP-54F28 is a first-in-class recombinant fusion protein of the extracellular domain of the human frizzled (FZD) 8… 
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