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OMP-54F28
Known as:
OMP 54F28
National Institutes of Health
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Related topics
Related topics
4 relations
Broader (4)
G-Protein-Coupled Receptors
Immunoglobulin Fc Fragments
Ipafricept
Recombinant Fusion Proteins
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Abstract 4233: Wnt pathway antagonist ipafricept (FZD8-Fc, OMP-54F28) inhibits tumor growth and reduces tumor-initiating cell frequency in ovarian patient-derived xenograft models
M. Fischer
,
W. Yen
,
+9 authors
T. Hoey
2015
Corpus ID: 75571523
Ovarian cancer is the deadliest gynecologic malignancy and the fifth leading cause of death from cancer in women in the U.S. The…
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2014
2014
Abstract 1907: Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor growth and reduces tumor-initiating cell frequency in patient-derived hepatocellular carcinoma and ovarian cancer xenograft…
P. Yeung
,
L. Beviglia
,
+8 authors
A. Kapoun
2014
Corpus ID: 70956738
The Wnt/beta-catenin pathway, which signals through the Frizzled (FZD) receptor family and several co-receptors, has long been…
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2013
2013
Abstract B79: A first-in-human Phase 1 study of anti-cancer stem cell (CSC) agent OMP-54F28 (FZD8-Fc) targeting the WNT pathway in patients with advanced solid tumors.
David C. Smith
,
M. Gordon
,
+8 authors
A. Jimeno
2013
Corpus ID: 83543505
Introduction: OMP-54F28 is a first-in-class recombinant fusion protein of the extracellular domain of the human frizzled (FZD) 8…
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