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OMP-54F28
Known as:
OMP 54F28
National Institutes of Health
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Related topics
Related topics
4 relations
Broader (4)
G-Protein-Coupled Receptors
Immunoglobulin Fc Fragments
Ipafricept
Recombinant Fusion Proteins
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Wnt signaling dynamics in head and neck squamous cell cancer tumor‐stroma interactions
Phuong N Le
,
S. Keysar
,
+10 authors
A. Jimeno
Molecular Carcinogenesis
2018
Corpus ID: 53107049
Wnt pathway activation maintains the cancer stem cell (CSC) phenotype and promotes tumor progression, making it an attractive…
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Highly Cited
2017
Highly Cited
2017
A First-in-Human Phase I Study of the Anticancer Stem Cell Agent Ipafricept (OMP-54F28), a Decoy Receptor for Wnt Ligands, in Patients with Advanced Solid Tumors
A. Jimeno
,
M. Gordon
,
+9 authors
David C. Smith
Clinical Cancer Research
2017
Corpus ID: 34236971
Purpose: Wnt signaling is implicated in tumor cell dedifferentiation and cancer stem cell function. Ipafricept (OMP-54F28) is a…
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Review
2017
Review
2017
Molecular genetics and targeted therapy of WNT-related human diseases (Review)
Masuko Katoh
,
M. Katoh
International Journal of Molecular Medicine
2017
Corpus ID: 4910181
Canonical WNT signaling through Frizzled and LRP5/6 receptors is transduced to the WNT/β-catenin and WNT/stabilization of…
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Review
2015
Review
2015
Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28.
Phuong N Le
,
J. McDermott
,
A. Jimeno
Pharmacology and Therapeutics
2015
Corpus ID: 22759326
2015
2015
Abstract 4233: Wnt pathway antagonist ipafricept (FZD8-Fc, OMP-54F28) inhibits tumor growth and reduces tumor-initiating cell frequency in ovarian patient-derived xenograft models
M. Fischer
,
W. Yen
,
+9 authors
T. Hoey
2015
Corpus ID: 75571523
Ovarian cancer is the deadliest gynecologic malignancy and the fifth leading cause of death from cancer in women in the U.S. The…
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2014
2014
Abstract 1907: Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor growth and reduces tumor-initiating cell frequency in patient-derived hepatocellular carcinoma and ovarian cancer xenograft…
P. Yeung
,
L. Beviglia
,
+8 authors
A. Kapoun
2014
Corpus ID: 70956738
The Wnt/beta-catenin pathway, which signals through the Frizzled (FZD) receptor family and several co-receptors, has long been…
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2013
2013
Abstract B79: A first-in-human Phase 1 study of anti-cancer stem cell (CSC) agent OMP-54F28 (FZD8-Fc) targeting the WNT pathway in patients with advanced solid tumors.
David C. Smith
,
M. Gordon
,
+8 authors
A. Jimeno
2013
Corpus ID: 83543505
Introduction: OMP-54F28 is a first-in-class recombinant fusion protein of the extracellular domain of the human frizzled (FZD) 8…
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