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OGX-427

National Institutes of Health

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ApatorsenOligonucleotides

Papers overview

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2016
2016
Abstract 3759: Inhibition of heat shock protein 27 (Hsp27) expression by apatorsen as a therapeutic strategy in breast cancer
Background: Heat shock protein 27 (Hsp27) is over-expressed in a number of cancers, including breast cancer, and interacts with… 
2013
2013
The Pacific trial: A randomized phase II study of OGX-427 in men with metastatic castration-resistant prostate cancer (mCRPC) and PSA progression while receiving abiraterone acetate (AA).
TPS5101 Background: Heat Shock Protein 27 (Hsp27) is a multi-functional chaperone protein that regulates cell signaling and… 
2013
2013
The Borealis-2 clinical trial: A randomized phase II study of OGX-427 plus docetaxel versus docetaxel alone in relapsed/refractory metastatic urothelial cancer.
TPS4577 Background: Heat shock protein 27 (Hsp27) is over-expressed in many cancers including bladder, lung, prostate, and breast… 
2013
2013
Double-blind randomized phase II trial of carboplatin and pemetrexed with or without OGX-427 in patients with previously untreated stage IV non-squamous non-small-cell lung cancer (NSCLC): The Spruce…
TPS8120 Background: OGXE427 is an antisense oligonucleotide (ASO) designed to bind to Hsp27 (heat shock protein 27) mRNA… 
2013
2013
Abstract IA28: Targeting stress-induced molecular chaperones CLU and Hsp27 to inhibit EMT and metastases
Stress-activated adaptive pathways help drive cancer cell survival, metastases, and acquired treatment resistance. Heat shock and… 
2012
2012
A phase I trial of intravesical antisense oligonucleotide targeting heat shock protein 27 (OGX-427) for the treatment of non-muscle-invasive bladder cancer.
286 Background: The treatment options to prevent recurrence and progression in patients with non-muscle invasive bladder cancer… 
2012
2012
Kombination von Gemcitabin und Cisplatin mit OGX-427
Für eine Studie zur First-Line-Therapie beim lokal fortgeschrittenen oder metastasierten Urothelkarzinom werden noch Patienten… 
2012
2012
A phase I trial of intravesical antisense oligonucleotide targeting heat shock protein 27 (OGX-427) for the treatment of non-muscle-invasive bladder cancer.
286 Background: The treatment options to prevent recurrence and progression in patients with non-muscle invasive bladder cancer… 
2012
2012
A randomized phase II study of OGX-427 plus prednisone versus prednisone alone in patients with chemotherapy-naive metastatic castration-resistant prostate cancer.
121 Background: Heat Shock Protein 27 (Hsp27) is a stress-activated, multi-functional chaperone protein highly expressed in… 
2010
2010
Phase I trial of OGX-427, a 2'methoxyethyl antisense oligonucleotide (ASO), against heat shock protein 27 (Hsp27): Final results.
3077 Background: Hsp27 is a chaperone protein that affects multiple pathways implicated in cancer progression and treatment… 
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