OGX-011

Known as: ISIS 112989 
A mixed-backbone antisense oligodeoxynucleotide with chemosensitizing properties. OGX-011 inhibits testosterone-repressed prostate message-2 (TRPM-2… (More)

Topic mentions per year

Topic mentions per year

2004-2016
024620042016

Papers overview

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2014
2014
PURPOSE Despite recent improvements in therapeutic management of osteosarcoma, ongoing challenges in improving the response to… (More)
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2012
2012
Background:The objective of this study was to investigate whether the therapeutic activity of sorafenib could be enhanced by… (More)
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2011
2011
Small-molecule inhibitors of Hsp90 show promise in the treatment of castrate-resistant prostate cancer (CRPC); however, these… (More)
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2011
2011
PURPOSE Clusterin (CLU) is an antiapoptotic, stress-induced protein conferring treatment resistance when overexpressed. This… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE To determine the clinical activity of OGX-011, an antisense inhibitor of clusterin, in combination with docetaxel… (More)
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2009
2009
PURPOSE Clusterin is an antiapoptotic protein activated in response to cellular stress. OGX-011 is a second-generation antisense… (More)
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2009
2009
5012 Background: Clusterin is a cytoprotective chaperone protein associated with CRPC progression. OGX is a 2'-methoxyethyl… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVES To characterize changes in secretory clusterin (sCLU) expression in prostate cancer cells after treatment with… (More)
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2008
2008
PURPOSE Clusterin is a cytoprotective chaperone protein that promotes cell survival and confers broad-spectrum treatment… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Clusterin is a cytoprotective chaperone protein that promotes cell survival and confers broad-spectrum treatment… (More)
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