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OGX-011

Known as: ISIS 112989 
A mixed-backbone antisense oligodeoxynucleotide with chemosensitizing properties. OGX-011 inhibits testosterone-repressed prostate message-2 (TRPM-2… Expand
National Institutes of Health

Papers overview

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2017
2017
BACKGROUND Docetaxel and cabazitaxel improve overall survival compared with mitoxantrone in patients with metastatic castration… Expand
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2012
2012
PURPOSE Clusterin (CLU), an antiapoptotic, stress-associated protein, confers resistance to therapy when overexpressed. This… Expand
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Highly Cited
2011
Highly Cited
2011
PURPOSE Clusterin (CLU) is an antiapoptotic, stress-induced protein conferring treatment resistance when overexpressed. This… Expand
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2011
2011
Small-molecule inhibitors of Hsp90 show promise in the treatment of castrate-resistant prostate cancer (CRPC); however, these… Expand
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Highly Cited
2010
Highly Cited
2010
PURPOSE To determine the clinical activity of OGX-011, an antisense inhibitor of clusterin, in combination with docetaxel… Expand
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2009
2009
PURPOSE Clusterin is an antiapoptotic protein activated in response to cellular stress. OGX-011 is a second-generation antisense… Expand
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Highly Cited
2008
Highly Cited
2008
OBJECTIVES To characterize changes in secretory clusterin (sCLU) expression in prostate cancer cells after treatment with… Expand
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Highly Cited
2008
Highly Cited
2008
PURPOSE Clusterin is a cytoprotective chaperone protein that promotes cell survival and confers broad-spectrum treatment… Expand
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Highly Cited
2007
Highly Cited
2007
The pharmacokinetics of a 2'-O-(2-methoxyethyl)-modified oligonucleotide, ISIS 301012 [targeting human apolipoprotein B-100 (apoB… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Clusterin is a cytoprotective chaperone protein that promotes cell survival and confers broad-spectrum treatment… Expand
Is this relevant?