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OGX-011

Known as: ISIS 112989 
A mixed-backbone antisense oligodeoxynucleotide with chemosensitizing properties. OGX-011 inhibits testosterone-repressed prostate message-2 (TRPM-2… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Purpose: Clusterin (CLU) is an antiapoptotic, stress-induced protein conferring treatment resistance when overexpressed. This… Expand
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Highly Cited
2010
Highly Cited
2010
PURPOSE To determine the clinical activity of OGX-011, an antisense inhibitor of clusterin, in combination with docetaxel… Expand
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Highly Cited
2010
Highly Cited
2010
Secretory clusterin (sCLU) is a stress-activated, cytoprotective chaperone that confers broad-spectrum cancer treatment… Expand
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2009
2009
Purpose: Clusterin is an antiapoptotic protein activated in response to cellular stress. OGX-011 is a second-generation antisense… Expand
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2009
2009
To characterize changes in clusterin (sCLU‐2) expression in bladder cancer cells after continuous treatment with gemcitabine and… Expand
Highly Cited
2008
Highly Cited
2008
To characterize changes in secretory clusterin (sCLU) expression in prostate cancer cells after treatment with docetaxel and to… Expand
Highly Cited
2008
Highly Cited
2008
Purpose: Clusterin is a cytoprotective chaperone protein that promotes cell survival and confers broad-spectrum treatment… Expand
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Highly Cited
2007
Highly Cited
2007
The pharmacokinetics of a 2′-O-(2-methoxyethyl)-modified oligonucleotide, ISIS 301012 [targeting human apolipoprotein B-100 (apoB… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Clusterin is a cytoprotective chaperone protein that promotes cell survival and confers broad-spectrum treatment… Expand