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OGX-011

Known as: ISIS 112989 
A mixed-backbone antisense oligodeoxynucleotide with chemosensitizing properties. OGX-011 inhibits testosterone-repressed prostate message-2 (TRPM-2… 
National Institutes of Health

Papers overview

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Review
2012
Review
2012
Review
2011
Highly Cited
2011
Highly Cited
2011
Purpose: Clusterin (CLU) is an antiapoptotic, stress-induced protein conferring treatment resistance when overexpressed. This… 
Highly Cited
2010
Highly Cited
2010
PURPOSE To determine the clinical activity of OGX-011, an antisense inhibitor of clusterin, in combination with docetaxel… 
Highly Cited
2008
Highly Cited
2008
Purpose: Clusterin is a cytoprotective chaperone protein that promotes cell survival and confers broad-spectrum treatment… 
Highly Cited
2008
Highly Cited
2008
To characterize changes in secretory clusterin (sCLU) expression in prostate cancer cells after treatment with docetaxel and to… 
Review
2008
Review
2008
Background: Clusterin is a stress-induced cytoprotective chaperone protein, regulated by HSF1, and functions similarly to a small… 
Highly Cited
2007
Highly Cited
2007
The pharmacokinetics of a 2′-O-(2-methoxyethyl)-modified oligonucleotide, ISIS 301012 [targeting human apolipoprotein B-100 (apoB… 
Highly Cited
2005
Highly Cited
2005
BACKGROUND Clusterin is a cytoprotective chaperone protein that promotes cell survival and confers broad-spectrum treatment… 
Review
2005
Review
2005
Improved understanding of the molecular mechanisms that mediate cancer progression and therapeutic resistance has identified many…