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O-methyl-methionine-dichloroplatinum(II)

Known as: Pt(O-Me-Met)Cl2, Pt(O-methyl-methionine)Cl2 
 
National Institutes of Health

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Broader (1)

Organoplatinum Compounds

Papers overview

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2013
2013
A new platinum(II) compound anticancer drug candidate with selective cytotoxicity for breast cancer cells
[Pt(O,O′-acac)(γ-acac)(DMS)] (PtAcD) is able to induce apoptosis in various human cancer cells, including the cisplatin-resistant… Expand
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2011
2011
The platinum (II) complex [Pt(O,O'-acac)(γ-acac)(DMS)] alters the intracellular calcium homeostasis in MCF-7 breast cancer cells.
It was previously demonstrated that [Pt(O,O'-acac)(γ-acac)(DMS)] exerted toxic effects at high doses, whilst sub-cytotoxic… Expand
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2011
2011
The developmental neurotoxicity study of platinum compounds. Effects of cisplatin versus a novel Pt(II) complex on rat cerebellum.
In the field of experimental oncology, many efforts are being carried out to search new platinum-based drugs overcoming the CNS… Expand
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2011
2011
The signalling axis mediating neuronal apoptosis in response to [Pt(O,O'-acac)(γ-acac)(DMS)].
It was previously shown that [Pt(O,O'-acac)(γ-acac)(DMS)] induces apoptosis in various cancer cells and exerts antimetastatic… Expand
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2011
2011
Developing Central Nervous System and Vulnerability to Platinum Compounds
Comparative studies on the effects of the platinum complexes in use or in clinical trials are carried out in order to discover… Expand
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2010
2010
Sublethal concentrations of the platinum(II) complex [Pt(O,O'-acac)(gamma-acac)(DMS)] alter the motility and induce anoikis in MCF-7 cells.
BACKGROUND AND PURPOSE We showed previously that a new Pt(II) complex ([Pt(O,O'-acac)(gamma-acac)(DMS)]) exerted high and fast… Expand
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2009
2009
Reactivity of platinum-based antitumor drugs towards a Met- and His-rich 20mer peptide corresponding to the N-terminal domain of human copper transporter 1
Cellular uptake of platinum-based antitumor drugs is a critical step in the mechanism of the drug action and associated… Expand
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2009
2009
Hard/soft selectivity in ligand substitution reactions of beta-diketonate platinum(II) complexes.
The reactivity of platinum(II) complexes of the type [PtCl(O,O-acac)(L)] (1) and [Pt(O,O-acac)(gamma-acac)(L)] (2) (L = DMSO, a… Expand
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2008
2008
[Pt(O,O'-acac)(gamma-acac)(DMS)], a new Pt compound exerting fast cytotoxicity in MCF-7 breast cancer cells via the mitochondrial apoptotic pathway.
BACKGROUND AND PURPOSE We showed previously that a new Pt complex containing an O,O'-chelated acetylacetonate ligand (acac) and a… Expand
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2007
2007
New platinum(II) complexes containing both an O,O'-chelated acetylacetonate ligand and a sulfur ligand in the platinum coordination sphere induce apoptosis in HeLa cervical carcinoma cells.
We report the cytotoxic effects obtained in HeLa cells of three newly synthesized platinum complexes containing both an O,O… Expand
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