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O-methyl-methionine-dichloroplatinum(II)

Known as: Pt(O-Me-Met)Cl2, Pt(O-methyl-methionine)Cl2 
National Institutes of Health

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Broader (1)

Organoplatinum Compounds

Papers overview

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2013
2013
A new platinum(II) compound anticancer drug candidate with selective cytotoxicity for breast cancer cells
[Pt(O,O′-acac)(γ-acac)(DMS)] (PtAcD) is able to induce apoptosis in various human cancer cells, including the cisplatin-resistant… 
Highly Cited
2011
Highly Cited
2011
The platinum (II) complex [Pt(O,O'-acac)(γ-acac)(DMS)] alters the intracellular calcium homeostasis in MCF-7 breast cancer cells.
2011
2011
The signalling axis mediating neuronal apoptosis in response to [Pt(O,O'-acac)(γ-acac)(DMS)].
2011
2011
The developmental neurotoxicity study of platinum compounds. Effects of cisplatin versus a novel Pt(II) complex on rat cerebellum.
2011
2011
Developing Central Nervous System and Vulnerability to Platinum Compounds
Comparative studies on the effects of the platinum complexes in use or in clinical trials are carried out in order to discover… 
2010
2010
Sublethal concentrations of the platinum(II) complex [Pt(O,O′‐acac)(γ‐acac)(DMS)] alter the motility and induce anoikis in MCF‐7 cells
Background and purpose:  We showed previously that a new Pt(II) complex ([Pt(O,O′‐acac)(γ‐acac)(DMS)]) exerted high and fast… 
Highly Cited
2009
Highly Cited
2009
Reactivity of platinum-based antitumor drugs towards a Met- and His-rich 20mer peptide corresponding to the N-terminal domain of human copper transporter 1
Cellular uptake of platinum-based antitumor drugs is a critical step in the mechanism of the drug action and associated… 
Highly Cited
2008
Highly Cited
2008
[Pt(O,O′‐acac)(γ‐acac)(DMS)], a new Pt compound exerting fast cytotoxicity in MCF‐7 breast cancer cells via the mitochondrial apoptotic pathway
We showed previously that a new Pt complex containing an O,O′‐chelated acetylacetonate ligand (acac) and a dimethylsulphide in… 
2007
2007
New platinum(II) complexes containing both an O,O'-chelated acetylacetonate ligand and a sulfur ligand in the platinum coordination sphere induce apoptosis in HeLa cervical carcinoma cells.
2004
2004
Alkynyldiphenylphosphine d8 (Pt, Rh, Ir) complexes: contrasting behavior toward cis-[Pt(C6F5)2(THF)2].
The synthesis and characterization of a series of mononuclear d(8) complexes with at least two P-coordinated alkynylphosphine… 
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