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O-acetylhomoserine (thiol)-lyase activity

Known as: L-methionine formation, direct, from O-acetyl-L-homoserine, O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity, L-methionine synthesis, direct, from O-acetyl-L-homoserine 
Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing… Expand
National Institutes of Health

Papers overview

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2011
2011
A novel mechanism of sulfur transfer catalyzed by O-acetylhomoserine sulfhydrylase in the methionine-biosynthetic pathway of Wolinella succinogenes.
O-Acetylhomoserine sulfhydrylase (OAHS) is a pyridoxal 5'-phosphate (PLP) dependent sulfide-utilizing enzyme in the L-cysteine… Expand
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2003
2003
In vivo analysis of various substrates utilized by cystathionine gamma-synthase and O-acetylhomoserine sulfhydrylase in methionine biosynthesis.
To gain insight into the evolution of the methionine biosynthesis pathway, in vivo complementation tests were performed. The… Expand
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2002
2002
Degradation of methanethiol in a continuously operated upflow anaerobic sludge-blanket reactor.
The feasibility of anaerobic treatment of wastewater containing volatile organic sulfur compounds was investigated using biomass… Expand
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1999
1999
Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA).
Oxidation of methionine residues in proteins to methionine sulfoxide can be reversed by the enzyme peptide methionine sulfoxide… Expand
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1998
1998
Direct sulfhydrylation for methionine biosynthesis in Leptospira meyeri.
A gene library of the Leptospira meyeri serovar semaranga strain Veldrat S.173 DNA has been constructed in a mobilizable cosmid… Expand
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1975
1975
Purification and properties of homoserine transacetylase from Bacillus polymyxa.
Homoserine transacetylase (EC 2.3.1.31), the first enzyme of methionine biosynthesis, has been purified to near homogeneity from… Expand
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1973
1973
Studies on beta-cystathionase and omicron-acetylhomoserine sulfhydrylase as the enzymes of alternative methionine biosynthetic pathways in Aspergillus nidulans.
 
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1971
1971
The enzymic formation of O-acetylhomoserine in Bacillus subtilis and its regulation by methionine and S-adenosylmethionine.
Abstract Cell-free extracts of Bacillus subtilis catalyze the formation of O-acetylhomoserine from acetyl-CoA and L-homoserine… Expand
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1970
1970
Hydrogen sulphide production by yeast under conditions of methionine, pantothenate or vitamin B6 deficiency.
SUMMARY: Methionine-requiring mutants of Saccharomyces cerevisiae produce large amounts of hydrogen sulphide from sulphate… Expand
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1967
1967
Acyl derivatives of homoserine as substrates for homocysteine synthesis in Neurospora crassa, yeast, and Escherichia coli.
Abstract "Activated" forms of l-homoserine have been shown to be more readily utilized as substrates than homoserine for the… Expand
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