O-(6)-methylguanine

Known as: O(6)-methylguanine, O6-methylguanine, 6-methylguanine 
 
National Institutes of Health

Papers overview

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Review
2016
Review
2016
Temozolomide (TMZ) is an oral alkylating agent used to treat glioblastoma multiforme (GBM) and astrocytomas. However, at least 50… (More)
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Highly Cited
2013
Highly Cited
2013
PURPOSE Radiotherapy with concomitant and adjuvant temozolomide is the standard of care for newly diagnosed glioblastoma (GBM). O… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE The standard of care for anaplastic gliomas is surgery followed by radiotherapy. The NOA-04 phase III trial compared… (More)
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Review
2006
Review
2006
Following the induction of DNA damage, a prominent route of cell inactivation is apoptosis. During the last ten years, specific… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Epigenetic silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Sporadic colorectal cancers often arise from a region of cells characterized by a "field defect" that has not been… (More)
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Review
2004
Review
2004
Alkylation lesions in DNA and RNA result from endogenous compounds, environmental agents and alkylating drugs. Simple methylating… (More)
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Highly Cited
2002
Highly Cited
2002
Methylating agents generate cytotoxic and mutagenic DNA damage. Cells use 3-methyladenine-DNA glycosylases to excise some… (More)
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Highly Cited
2000
Highly Cited
2000
Promoter hypermethylation is an important pathway for repression of gene transcription in cancer cells. We analyzed aberrant DNA… (More)
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Highly Cited
1999
Highly Cited
1999
The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the O6 position of guanine. MGMT… (More)
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