O(6)-Methylguanine-DNA Methyltransferase

Known as: Methylated-DNA--Protein-Cysteine Methyltransferase, MGMT, O(6)-MeG-DNA Methyltransferase 
An enzyme that transfers methyl groups from O(6)-methylguanine, and other methylated moieties of DNA, to a cysteine residue in itself, thus repairing… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
The flavonoids, baicalin (5,6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one-7-O-d-β-glucuronic acid) 1 and its aglycone, baicalein 2… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Most patients with glioblastoma are older than 60 years, but treatment guidelines are based on trials in patients aged… (More)
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Highly Cited
2010
Highly Cited
2010
To take complete advantage of information on within-species polymorphism and divergence from close relatives, one needs to know… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE The standard of care for anaplastic gliomas is surgery followed by radiotherapy. The NOA-04 phase III trial compared… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE Standard therapy for glioblastoma (GBM) is temozolomide (TMZ) administration, initially concurrent with radiotherapy (RT… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE In the setting of a prospective clinical trial, we determined the predictive value of the methylation status of the O-6… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND The DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) inhibits the killing of tumor cells by alkylating… (More)
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Highly Cited
1999
Highly Cited
1999
The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the O6 position of guanine. MGMT… (More)
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Highly Cited
1999
Highly Cited
1999
Recent evidence suggests that tumor cells may release DNA into the circulation, which is enriched in the serum and plasma… (More)
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Highly Cited
1994
Highly Cited
1994
An understanding of DNA methylation and its potential role in gene control during development, aging and cancer has been hampered… (More)
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